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Query author contributions in Reactome

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Details on Person Signalase cleaves prepro-NS4B

Class:IdReaction:9918871
_displayNameSignalase cleaves prepro-NS4B
_doReleaseTRUE
_timestamp2025-10-30 11:56:52
authored[InstanceEdit:9918869] Stephan, Ralf, 2024-08-18
catalystActivity[CatalystActivity:265014] serine-type endopeptidase activity of Signal Peptidase [endoplasmic reticulum membrane]
compartment[Compartment:70101] cytosol
created[InstanceEdit:9918874] Stephan, Ralf, 2024-08-18
disease[Disease:3244610] dengue disease
edited[InstanceEdit:9966335] Stephan, Ralf, 2025-09-18
input[EntityWithAccessionedSequence:9918870] prepro-NS4B [endoplasmic reticulum membrane] [Dengue virus type 2]
[SimpleEntity:29356] H2O [cytosol]
internalReviewed[InstanceEdit:9925762] Orlic-Milacic, Marija, 2024-10-23
isChimericFALSE
literatureReference[LiteratureReference:9918765] Processing of nonstructural proteins NS4A and NS4B of dengue 2 virus in vitro and in vivo
[LiteratureReference:9918826] Maturation of dengue virus nonstructural protein 4B in monocytes enhances production of dengue hemorrhagic fever-associated chemokines and cytokines
[LiteratureReference:9920040] Inhibition of alpha/beta interferon signaling by the NS4B protein of flaviviruses
modified[InstanceEdit:9918886] Stephan, Ralf, 2024-08-18
[InstanceEdit:9920038] Stephan, Ralf, 2024-08-29
[InstanceEdit:9924077] Stephan, Ralf, 2024-10-07
[InstanceEdit:9924657] Stephan, Ralf, 2024-10-16
[InstanceEdit:9925761] Stephan, Ralf, 2024-10-23
[InstanceEdit:9945835] Stephan, Ralf, 2025-04-19
[InstanceEdit:9949486] Stephan, Ralf, 2025-05-22
[InstanceEdit:9963605] Stephan, Ralf, 2025-08-15
[InstanceEdit:9964208] Stephan, Ralf, 2025-08-20
[InstanceEdit:9966309] Stephan, Ralf, 2025-09-16
[InstanceEdit:9966334] Stephan, Ralf, 2025-09-18
[InstanceEdit:9966338] Stephan, Ralf, 2025-09-19
[InstanceEdit:9970207] Stephan, Ralf, 2025-10-29
[InstanceEdit:9970441] Stephan, Ralf, 2025-10-30
[InstanceEdit:9970472] Stephan, Ralf, 2025-10-30
nameSignalase cleaves prepro-NS4B
output[EntityWithAccessionedSequence:9918783] NS4B [endoplasmic reticulum membrane] [Dengue virus type 2]
[EntityWithAccessionedSequence:9918873] Peptide 2K [cytosol] [Dengue virus type 2]
precedingEvent
previousReviewStatus[ReviewStatus:9821383] three stars
relatedSpecies[Species:3244621] Dengue virus type 2
releaseDate2025-12-08
reviewed[InstanceEdit:9966332] Mansur, Daniel Santos, 2025-09-18
[InstanceEdit:9970439] Roque Ascenção, Fernando, 2025-10-29
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9918881] R-HSA-9918871.1
summation[Summation:9920083] A host signalase cleaves 2K-NS4B (prepro-NS4B), producing NS...
(hasEvent)[Pathway:9918432] Maturation of DENV proteins [Homo sapiens]
(precedingEvent)[Reaction:9924274] NS4B forms a dimer [Homo sapiens]
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No pathways have been reviewed or authored by Signalase cleaves prepro-NS4B (9918871)
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