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Details on Person NS2B3 cleaves polyprotein

Class:IdReaction:9918817
_displayNameNS2B3 cleaves polyprotein
_doReleaseTRUE
_timestamp2025-10-30 11:48:09
authored[InstanceEdit:9918832] Stephan, Ralf, 2024-08-18
catalystActivity[CatalystActivity:9919951] serine-type endopeptidase activity of NS2B3 [cytosol]
compartment[Compartment:12045] endoplasmic reticulum membrane
created[InstanceEdit:9918778] Stephan, Ralf, 2024-08-18
disease[Disease:3244610] dengue disease
edited[InstanceEdit:9966335] Stephan, Ralf, 2025-09-18
input[EntityWithAccessionedSequence:9918800] folded HyPro-Polyprotein [endoplasmic reticulum membrane] [Dengue virus type 2]
[SimpleEntity:113519] H2O [endoplasmic reticulum lumen]
[SimpleEntity:113519] H2O [endoplasmic reticulum lumen]
internalReviewed[InstanceEdit:9925762] Orlic-Milacic, Marija, 2024-10-23
[InstanceEdit:9959999] Matthews, Lisa, 2025-07-04
isChimericFALSE
literatureReference[LiteratureReference:9918765] Processing of nonstructural proteins NS4A and NS4B of dengue 2 virus in vitro and in vivo
[LiteratureReference:9918797] Cleavage preference distinguishes the two-component NS2B-NS3 serine proteinases of Dengue and West Nile viruses
[LiteratureReference:9920139] Functional characterization of cis and trans activity of the Flavivirus NS2B-NS3 protease
[LiteratureReference:9945572] Bortezomib inhibits ZIKV/DENV by interfering with viral polyprotein cleavage via the ERAD pathway
[LiteratureReference:9966315] In vitro processing of dengue virus type 2 nonstructural proteins NS2A, NS2B, and NS3
modified[InstanceEdit:9918886] Stephan, Ralf, 2024-08-18
[InstanceEdit:9920038] Stephan, Ralf, 2024-08-29
[InstanceEdit:9920810] Stephan, Ralf, 2024-09-04
[InstanceEdit:9924077] Stephan, Ralf, 2024-10-07
[InstanceEdit:9924657] Stephan, Ralf, 2024-10-16
[InstanceEdit:9925761] Stephan, Ralf, 2024-10-23
[InstanceEdit:9939564] Stephan, Ralf, 2025-02-28
[InstanceEdit:9945578] Stephan, Ralf, 2025-04-16
[InstanceEdit:9949486] Stephan, Ralf, 2025-05-22
[InstanceEdit:9954776] Stephan, Ralf, 2025-06-09
[InstanceEdit:9960000] Stephan, Ralf, 2025-07-04
[InstanceEdit:9960002] Stephan, Ralf, 2025-07-04
[InstanceEdit:9963605] Stephan, Ralf, 2025-08-15
[InstanceEdit:9964206] Stephan, Ralf, 2025-08-20
[InstanceEdit:9966312] Stephan, Ralf, 2025-09-16
[InstanceEdit:9966334] Stephan, Ralf, 2025-09-18
[InstanceEdit:9966339] Stephan, Ralf, 2025-09-19
[InstanceEdit:9970207] Stephan, Ralf, 2025-10-29
[InstanceEdit:9970441] Stephan, Ralf, 2025-10-30
[InstanceEdit:9970472] Stephan, Ralf, 2025-10-30
nameNS2B3 cleaves polyprotein
output[EntityWithAccessionedSequence:9918791] C-prM-E-NS12A [endoplasmic reticulum membrane] [Dengue virus type 2]
[EntityWithAccessionedSequence:9918829] NS345 [endoplasmic reticulum membrane] [Dengue virus type 2]
[EntityWithAccessionedSequence:9918774] NS2B [endoplasmic reticulum membrane] [Dengue virus type 2]
precedingEvent
previousReviewStatus[ReviewStatus:9821383] three stars
regulatedBy[NegativeRegulation:9945564] Negative regulation by 'bortezomib [cytosol]'
[NegativeRegulation:9954786] Negative regulation by 'NS2B3:Dengue protease inhibitor [cytosol]'
relatedSpecies[Species:3244621] Dengue virus type 2
releaseDate2025-12-08
reviewed[InstanceEdit:9966332] Mansur, Daniel Santos, 2025-09-18
[InstanceEdit:9970439] Roque Ascenção, Fernando, 2025-10-29
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9918846] R-HSA-9918817.1
structureModified[InstanceEdit:9945578] Stephan, Ralf, 2025-04-16
[InstanceEdit:9954776] Stephan, Ralf, 2025-06-09
summation[Summation:9919958] NS2B:NS3 (NS2B3) peptidase cleaves the Dengue virus polyprot...
(hasEvent)[Pathway:9918432] Maturation of DENV proteins [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9918787] NS2B3 cleaves C-prM-E-NS1-NS2A [Homo sapiens]
[Reaction:9918798] NS2B binds to NS345 [Homo sapiens]
[Reaction:9918807] NS2B binds NS3 [Homo sapiens]
[Reaction:9918823] NS345:NS2B cleaves NS345 [Homo sapiens]
[BlackBoxEvent:9920087] Nonstructural proteins form the replication complex [Homo sapiens]
[Reaction:9920882] NS2B binds CGAS [Homo sapiens]
[Reaction:9947496] ACOT2 cleaves NS345 [Homo sapiens]
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No pathways have been reviewed or authored by NS2B3 cleaves polyprotein (9918817)
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