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Details on Person HyPro-polyprotein folds

Class:IdBlackBoxEvent:9918810
_displayNameHyPro-polyprotein folds
_doReleaseTRUE
_timestamp2025-10-30 11:41:52
authored[InstanceEdit:9918832] Stephan, Ralf, 2024-08-18
compartment[Compartment:12045] endoplasmic reticulum membrane
created[InstanceEdit:9918778] Stephan, Ralf, 2024-08-18
disease[Disease:3244610] dengue disease
edited[InstanceEdit:9966335] Stephan, Ralf, 2025-09-18
goBiologicalProcess[GO_BiologicalProcess:384047] protein folding in endoplasmic reticulum
input[EntityWithAccessionedSequence:9918777] unfolded HyPro-Polyprotein [endoplasmic reticulum membrane] [Dengue virus type 2]
internalReviewed[InstanceEdit:9925762] Orlic-Milacic, Marija, 2024-10-23
isChimericFALSE
literatureReference[LiteratureReference:9918809] Cotranslational prolyl hydroxylation is essential for flavivirus biogenesis
[LiteratureReference:9924260] Dengue virus NS1 secretion is regulated via importin-subunit β1 controlling expression of the chaperone GRp78 and targeted by the clinical drug ivermectin
[LiteratureReference:9954440] Defining Hsp70 Subnetworks in Dengue Virus Replication Reveals Key Vulnerability in Flavivirus Infection
modified[InstanceEdit:9918886] Stephan, Ralf, 2024-08-18
[InstanceEdit:9918965] Stephan, Ralf, 2024-08-19
[InstanceEdit:9920038] Stephan, Ralf, 2024-08-29
[InstanceEdit:9924077] Stephan, Ralf, 2024-10-07
[InstanceEdit:9924657] Stephan, Ralf, 2024-10-16
[InstanceEdit:9925438] Stephan, Ralf, 2024-10-17
[InstanceEdit:9925761] Stephan, Ralf, 2024-10-23
[InstanceEdit:9945578] Stephan, Ralf, 2025-04-16
[InstanceEdit:9954417] Stephan, Ralf, 2025-06-07
[InstanceEdit:9963605] Stephan, Ralf, 2025-08-15
[InstanceEdit:9964204] Stephan, Ralf, 2025-08-20
[InstanceEdit:9966334] Stephan, Ralf, 2025-09-18
[InstanceEdit:9966337] Stephan, Ralf, 2025-09-19
[InstanceEdit:9970207] Stephan, Ralf, 2025-10-29
[InstanceEdit:9970441] Stephan, Ralf, 2025-10-30
[InstanceEdit:9970472] Stephan, Ralf, 2025-10-30
nameHyPro-polyprotein folds
output[EntityWithAccessionedSequence:9918800] folded HyPro-Polyprotein [endoplasmic reticulum membrane] [Dengue virus type 2]
precedingEvent
previousReviewStatus[ReviewStatus:9821383] three stars
regulatedBy[Requirement:9920072] Requirement by 'HSPA5 [endoplasmic reticulum lumen]'
[Requirement:9920007] Requirement by 'DNAJB11 [endoplasmic reticulum lumen]'
[Requirement:9920058] Requirement by 'p-DNAJC3 [endoplasmic reticulum lumen]'
[Requirement:9920103] Requirement by 'DNAJC10 [endoplasmic reticulum lumen]'
[Requirement:9925433] Requirement by 'HYOU1 [endoplasmic reticulum lumen]'
regulationReference[RegulationReference:9945585] Requirement by 'HSPA5 [endoplasmic reticulum lumen]' Dengue virus NS1 secretion is regulated via importin-subunit β1 controlling expression of the chaperone GRp78 and targeted by the clinical drug ivermectin
relatedSpecies[Species:3244621] Dengue virus type 2
releaseDate2025-12-08
reviewed[InstanceEdit:9966332] Mansur, Daniel Santos, 2025-09-18
[InstanceEdit:9970439] Roque Ascenção, Fernando, 2025-10-29
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9918854] R-HSA-9918810.1
structureModified[InstanceEdit:9920038] Stephan, Ralf, 2024-08-29
[InstanceEdit:9925438] Stephan, Ralf, 2024-10-17
summation[Summation:9919969] Folding of the Dengue virus polyprotein involves the Hsp70-d...
(hasEvent)[Pathway:9918432] Maturation of DENV proteins [Homo sapiens]
(precedingEvent)[Reaction:9918772] Dengue polyprotein cis-auto-cleaves [Homo sapiens]
[Reaction:9918817] NS2B3 cleaves polyprotein [Homo sapiens]
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No pathways have been reviewed or authored by HyPro-polyprotein folds (9918810)
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