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Details on Person NS2B binds NS3

Class:Id	Reaction:9918807
_displayName	NS2B binds NS3
_doRelease	TRUE
_timestamp	2025-10-30 11:46:45
authored	[InstanceEdit:9918832] Stephan, Ralf, 2024-08-18
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9918778] Stephan, Ralf, 2024-08-18
disease	[Disease:3244610] dengue disease
edited	[InstanceEdit:9966335] Stephan, Ralf, 2025-09-18
input	[EntityWithAccessionedSequence:9918774] NS2B [endoplasmic reticulum membrane] [Dengue virus type 2] [EntityWithAccessionedSequence:3244645] K27polyUb-NS3 [endoplasmic reticulum membrane] [Dengue virus type 2]
internalReviewed	[InstanceEdit:9925762] Orlic-Milacic, Marija, 2024-10-23
isChimeric	FALSE
literatureReference	[LiteratureReference:9919960] Pharmacophoric characteristics of dengue virus NS2B/NS3pro inhibitors: a systematic review of the most promising compounds [LiteratureReference:9919957] Both nonstructural proteins NS2B and NS3 are required for the proteolytic processing of dengue virus nonstructural proteins [LiteratureReference:9920097] Ligand-bound structures of the dengue virus protease reveal the active conformation [LiteratureReference:9920018] Biochemistry and medicinal chemistry of the dengue virus protease [LiteratureReference:9945287] Differential localization of dengue virus protease affects cell homeostasis and triggers to thrombocytopenia [LiteratureReference:9949470] Potential Role of Flavivirus NS2B-NS3 Proteases in Viral Pathogenesis and Anti-flavivirus Drug Discovery Employing Animal Cells and Models: A Review
modified	[InstanceEdit:9918886] Stephan, Ralf, 2024-08-18 [InstanceEdit:9920038] Stephan, Ralf, 2024-08-29 [InstanceEdit:9920810] Stephan, Ralf, 2024-09-04 [InstanceEdit:9920949] Stephan, Ralf, 2024-09-05 [InstanceEdit:9924077] Stephan, Ralf, 2024-10-07 [InstanceEdit:9924657] Stephan, Ralf, 2024-10-16 [InstanceEdit:9925441] Stephan, Ralf, 2024-10-17 [InstanceEdit:9925761] Stephan, Ralf, 2024-10-23 [InstanceEdit:9945288] Stephan, Ralf, 2025-04-13 [InstanceEdit:9949486] Stephan, Ralf, 2025-05-22 [InstanceEdit:9960009] Stephan, Ralf, 2025-07-04 [InstanceEdit:9963605] Stephan, Ralf, 2025-08-15 [InstanceEdit:9964206] Stephan, Ralf, 2025-08-20 [InstanceEdit:9966334] Stephan, Ralf, 2025-09-18 [InstanceEdit:9966337] Stephan, Ralf, 2025-09-19 [InstanceEdit:9970207] Stephan, Ralf, 2025-10-29 [InstanceEdit:9970441] Stephan, Ralf, 2025-10-30 [InstanceEdit:9970472] Stephan, Ralf, 2025-10-30
name	NS2B binds NS3
output	[Complex:3244638] NS2B3 [cytosol] [Dengue virus type 2]
precedingEvent	[Reaction:9918817] NS2B3 cleaves polyprotein [Homo sapiens] [BlackBoxEvent:9918810] HyPro-polyprotein folds [Homo sapiens] [Reaction:9918807] NS2B binds NS3 [Homo sapiens] [Reaction:9918772] Dengue polyprotein cis-auto-cleaves [Homo sapiens] [BlackBoxEvent:9918810] HyPro-polyprotein folds [Homo sapiens] [Reaction:9918823] NS345:NS2B cleaves NS345 [Homo sapiens] [Reaction:9918798] NS2B binds to NS345 [Homo sapiens] [Reaction:9918817] NS2B3 cleaves polyprotein [Homo sapiens] [Reaction:9918772] Dengue polyprotein cis-auto-cleaves [Homo sapiens] [BlackBoxEvent:9945766] NS3 is ubiquitinated [Homo sapiens] [Reaction:9918823] NS345:NS2B cleaves NS345 [Homo sapiens] [Reaction:9947496] ACOT2 cleaves NS345 [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
relatedSpecies	[Species:3244621] Dengue virus type 2
releaseDate	2025-12-08
reviewed	[InstanceEdit:9966332] Mansur, Daniel Santos, 2025-09-18 [InstanceEdit:9970439] Roque Ascenção, Fernando, 2025-10-29
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9918848] R-HSA-9918807.1
structureModified	[InstanceEdit:9920810] Stephan, Ralf, 2024-09-04 [InstanceEdit:9920949] Stephan, Ralf, 2024-09-05
summation	[Summation:9920000] Dengue virus proteins NS2B and NS3 bind non-covalently. The ...
(hasEvent)	[Pathway:9918432] Maturation of DENV proteins [Homo sapiens]
(precedingEvent)	[Reaction:3244618] DENV protease NS2B3 binds STING [Homo sapiens] [BlackBoxEvent:9918787] NS2B3 cleaves C-prM-E-NS1-NS2A [Homo sapiens] [Reaction:9918813] NS2B3 cleaves NS4AB [Homo sapiens] [Reaction:9918817] NS2B3 cleaves polyprotein [Homo sapiens] [Reaction:9918876] NS2B3 cleaves prepro-C at the C-prM junction [Homo sapiens] [Reaction:9920952] NS2B3 binds IKBKE [Homo sapiens] [Reaction:9921160] NS2B3 binds NFKBIB [Homo sapiens] [Reaction:9921168] NS2B3 binds NFKBIA [Homo sapiens] [Reaction:9921595] NS2B3 cleaves FAM134B [Homo sapiens] [BlackBoxEvent:9945387] NS2B3 localizes to nucleus [Homo sapiens] List all 11 refering instances
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No pathways have been reviewed or authored by NS2B binds NS3 (9918807)