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Details on Person Unknown peptidase cleaves NS1-NS2A

Class:IdReaction:9918780
_displayNameUnknown peptidase cleaves NS1-NS2A
_doReleaseTRUE
_timestamp2025-11-07 08:16:48
authored[InstanceEdit:9918832] Stephan, Ralf, 2024-08-18
catalystActivity[CatalystActivity:9918811] serine-type endopeptidase activity of unknown protease [endoplasmic reticulum membrane]
compartment[Compartment:17957] endoplasmic reticulum lumen
[Compartment:12045] endoplasmic reticulum membrane
created[InstanceEdit:9918778] Stephan, Ralf, 2024-08-18
disease[Disease:3244610] dengue disease
edited[InstanceEdit:9966335] Stephan, Ralf, 2025-09-18
input[EntityWithAccessionedSequence:9918767] NS12A [endoplasmic reticulum membrane] [Dengue virus type 2]
[SimpleEntity:113519] H2O [endoplasmic reticulum lumen]
internalReviewed[InstanceEdit:9925762] Orlic-Milacic, Marija, 2024-10-23
isChimericFALSE
literatureReference[LiteratureReference:9918768] Evidence that flavivirus NS1-NS2A cleavage is mediated by a membrane-bound host protease in the endoplasmic reticulum
[LiteratureReference:9966313] The endoplasmic reticulum (ER): a crucial cellular hub in flavivirus infection and potential target site for antiviral interventions
modified[InstanceEdit:9918886] Stephan, Ralf, 2024-08-18
[InstanceEdit:9920038] Stephan, Ralf, 2024-08-29
[InstanceEdit:9924077] Stephan, Ralf, 2024-10-07
[InstanceEdit:9924657] Stephan, Ralf, 2024-10-16
[InstanceEdit:9925761] Stephan, Ralf, 2024-10-23
[InstanceEdit:9949486] Stephan, Ralf, 2025-05-22
[InstanceEdit:9963605] Stephan, Ralf, 2025-08-15
[InstanceEdit:9964208] Stephan, Ralf, 2025-08-20
[InstanceEdit:9966312] Stephan, Ralf, 2025-09-16
[InstanceEdit:9966334] Stephan, Ralf, 2025-09-18
[InstanceEdit:9966338] Stephan, Ralf, 2025-09-19
[InstanceEdit:9970207] Stephan, Ralf, 2025-10-29
[InstanceEdit:9970441] Stephan, Ralf, 2025-10-30
[InstanceEdit:9970472] Stephan, Ralf, 2025-10-30
[InstanceEdit:9971554] Stephan, Ralf, 2025-11-07
nameUnknown peptidase cleaves NS1-NS2A
output[EntityWithAccessionedSequence:9918824] pre-NS1 [endoplasmic reticulum membrane] [Dengue virus type 2]
[EntityWithAccessionedSequence:9918789] NS2A [endoplasmic reticulum membrane] [Dengue virus type 2]
precedingEvent
previousReviewStatus[ReviewStatus:9821383] three stars
relatedSpecies[Species:3244621] Dengue virus type 2
releaseDate2025-12-08
reviewed[InstanceEdit:9966332] Mansur, Daniel Santos, 2025-09-18
[InstanceEdit:9970439] Roque Ascenção, Fernando, 2025-10-29
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9918840] R-HSA-9918780.1
summation[Summation:9920088] An unknown endoplasmic reticulum (ER)-membrane-bound host pe...
(hasEvent)[Pathway:9918432] Maturation of DENV proteins [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9919011] Pre-NS1 folds and is N-glycosylated [Homo sapiens]
[BlackBoxEvent:9920087] Nonstructural proteins form the replication complex [Homo sapiens]
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No pathways have been reviewed or authored by Unknown peptidase cleaves NS1-NS2A (9918780)
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