Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person In the retinal vasculature of mice, activation of the Dll4 p...
| Class:Id | Summation:9917532 |
|---|---|
| _displayName | In the retinal vasculature of mice, activation of the Dll4 p... |
| _timestamp | 2026-03-14 20:55:15 |
| created | [InstanceEdit:9917534] May, Bruce, 2024-08-06 |
| literatureReference | [LiteratureReference:9979477] Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting |
| modified | [InstanceEdit:9917561] May, Bruce, 2024-08-06 [InstanceEdit:9981372] May, Bruce, 2026-02-07 [InstanceEdit:9982319] May, Bruce, 2026-02-16 [InstanceEdit:9982412] May, Bruce, 2026-02-17 [InstanceEdit:9985149] May, Bruce, 2026-03-14 |
| text | In the retinal vasculature of mice, activation of the Dll4 promoter is induced by Vegfa acting via its receptor Vegfr2 (Lobov et al. 2007). MEF2 transcription factors activate the expression of critical sprouting angiogenesis regulators including DLL4, activated by VEGFA signaling (Sacilotto et al. 2016). VEGFA signaling induces the release of repressive histone deacetylases and recruitment of the histone acetyltransferase, EP300, to regulatory elements of MEF2 target genes, including DLL4 (Sacilotto et al. 2016). In response to VEGFA or Angiopoietin, phosphorylated ERG binds enhancers in the DLL4 gene located upstream of the transcription start site and within the third intron and activates transcription (Fish et al. 2017, Shah et al. 2017, Kalna et al. 2019, inferred from mouse homologs in Wythe et al. 2013). |
| (summation) | [BlackBoxEvent:9917438] Expression of DLL4 is positively regulated by VEGFA, MEF2A,C,D, and ERG in endothelial tip cell [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by In the retinal vasculature of mice, activation of the Dll4 p... (9917532)
