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Details on Person MEF2A,C,D:HDAC4,7,9:DLL4 gene releases HDAC4,7,9 and binds EP300 and ERG

Class:Id	Reaction:9917477
_displayName	MEF2A,C,D:HDAC4,7,9:DLL4 gene releases HDAC4,7,9 and binds EP300 and ERG
_timestamp	2026-03-18 16:42:42
authored	[InstanceEdit:9917427] Menon, Swapna, 2024-08-04
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9917489] May, Bruce, 2024-08-06
edited	[InstanceEdit:9917427] Menon, Swapna, 2024-08-04 [InstanceEdit:9980985] May, Bruce, 2026-02-04
input	[EntityWithAccessionedSequence:381325] EP300 [nucleoplasm] [Homo sapiens] [Complex:9917501] MEF2AC,D:HDAC4,7,9:DLL4 gene [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9980908] p-S96,S215,S276-ERG [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9985318] D'Eustachio, Peter, 2026-03-18
isChimeric	FALSE
literatureReference	[LiteratureReference:9917419] MEF2 transcription factors are key regulators of sprouting angiogenesis [LiteratureReference:9980942] The endothelial transcription factor ERG mediates Angiopoietin-1-dependent control of Notch signalling and vascular stability [LiteratureReference:9980900] Dynamic regulation of VEGF-inducible genes by an ERK/ERG/p300 transcriptional network [LiteratureReference:9980955] The Transcription Factor ERG Regulates Super-Enhancers Associated With an Endothelial-Specific Gene Expression Program
modified	[InstanceEdit:9917535] May, Bruce, 2024-08-06 [InstanceEdit:9979142] May, Bruce, 2026-01-15 [InstanceEdit:9980985] May, Bruce, 2026-02-04 [InstanceEdit:9982412] May, Bruce, 2026-02-17 [InstanceEdit:9985321] May, Bruce, 2026-03-18
name	MEF2A,C,D:HDAC4,7,9:DLL4 gene releases HDAC4,7,9 and binds EP300 and ERG
output	[DefinedSet:9917484] HDAC4,7,9 [nucleoplasm] [Homo sapiens] [Complex:9917446] MEF2A,C,D:p-S96,S215,S276-ERG:EP300:DLL4 gene [nucleoplasm] [Homo sapiens]
participantCellType	[PhysicalEntityCellType:9979132] EP300 [nucleoplasm] in endothelial tip cell [PhysicalEntityCellType:9979137] MEF2AC,D:HDAC4,7,9:DLL4 gene [nucleoplasm] in endothelial tip cell [PhysicalEntityCellType:9979141] HDAC4,7,9 [nucleoplasm] in endothelial tip cell [PhysicalEntityCellType:9979140] MEF2A,C,D:p-S96,S215,S276-ERG:EP300:DLL4 gene [nucleoplasm] in endothelial tip cell
regulatedBy	[PositiveRegulation:9674859] Positive regulation by 'VEGFA dimer [extracellular region]'
regulationReference	[RegulationReference:9917463] Positive regulation by 'VEGFA dimer [extracellular region]' MEF2 transcription factors are key regulators of sprouting angiogenesis
reviewStatus	[ReviewStatus:9821383] three stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9917521] R-HSA-9917477.1
structureModified	[InstanceEdit:9980985] May, Bruce, 2026-02-04
summation	[Summation:9917533] VEGFA signaling induces the release of repressive histone de...
(hasEvent)	[Pathway:9917416] Sprouting angiogenesis [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9917438] Expression of DLL4 is positively regulated by VEGFA, MEF2A,C,D, and ERG in endothelial tip cell [Homo sapiens]
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No pathways have been reviewed or authored by MEF2A,C,D:HDAC4,7,9:DLL4 gene releases HDAC4,7,9 and binds EP300 and ERG (9917477)