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Details on Person RNASEH1 cleaves RNA primer from nascent L strand, leaving RNA dinucleotides

Class:Id	Reaction:9915449
_displayName	RNASEH1 cleaves RNA primer from nascent L strand, leaving RNA dinucleotides
_doRelease	TRUE
_timestamp	2024-10-27 06:18:41
authored	[InstanceEdit:9915443] May, Bruce, 2024-07-07
catalystActivity	[CatalystActivity:9913641] RNA-DNA hybrid ribonuclease activity of RNASEH1:Mg2+ [mitochondrial matrix]
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9915438] May, Bruce, 2024-07-07
edited	[InstanceEdit:9915443] May, Bruce, 2024-07-07
input	[Complex:9914865] RNA dinucleotide:nascent H strand:mitochondrial genome:L strand RNA primer:nascent L strand [mitochondrial matrix] [Homo sapiens]
internalReviewed	[InstanceEdit:9918580] D'Eustachio, Peter, 2024-08-17
isChimeric	FALSE
literatureReference	[LiteratureReference:9915753] A two-nuclease pathway involving RNase H1 is required for primer removal at human mitochondrial OriL [LiteratureReference:9915769] Human RNase H1 discriminates between subtle variations in the structure of the heteroduplex substrate
modified	[InstanceEdit:9915761] May, Bruce, 2024-07-14 [InstanceEdit:9915792] May, Bruce, 2024-07-16 [InstanceEdit:9918581] May, Bruce, 2024-08-17 [InstanceEdit:9925847] May, Bruce, 2024-10-27 [InstanceEdit:9925851] May, Bruce, 2024-10-27 [InstanceEdit:9925854] May, Bruce, 2024-10-27
name	RNASEH1 cleaves RNA primer from nascent L strand, leaving RNA dinucleotides
output	[Complex:9915441] RNA dinucleotide:nascent L strand:mitochondrial genome:RNA dinucleotide:nascent H strand DNA [mitochondrial matrix] [Homo sapiens] [GenomeEncodedEntity:9914464] Light strand RNA primer [mitochondrial matrix] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9914858] RNASEH1 cleaves RNA primer from nascent H strand, leaving RNA dinucleotides [Homo sapiens] [BlackBoxEvent:9914498] POLG in the replisome polymerizes the L strand [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2024-12-04
reviewed	[InstanceEdit:9925848] Wu, Chyuan-Chuan, 2024-10-27
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9915461] R-HSA-9915449.1
structureModified	[InstanceEdit:9925847] May, Bruce, 2024-10-27
summation	[Summation:9915754] RNASEH1 cleaves the RNA primer from the 5' end of the nascen...
(hasEvent)	[Pathway:9913635] Strand-asynchronous mitochondrial DNA replication [Homo sapiens]
(precedingEvent)	[Reaction:9914870] MGME1 cleaves 5' DNA flap from nascent mitochondrial DNA [Homo sapiens] [Reaction:9915442] EXOG cleaves RNA dinucleotide from nascent mitochondrial DNA [Homo sapiens]
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No pathways have been reviewed or authored by RNASEH1 cleaves RNA primer from nascent L strand, leaving RNA dinucleotides (9915449)