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Details on Person EXOG cleaves RNA dinucleotide from nascent mitochondrial DNA

Class:Id	Reaction:9915442
_displayName	EXOG cleaves RNA dinucleotide from nascent mitochondrial DNA
_doRelease	TRUE
_timestamp	2024-10-27 06:07:24
authored	[InstanceEdit:9915443] May, Bruce, 2024-07-07
catalystActivity	[CatalystActivity:9914869] 5'-3' RNA exonuclease activity of EXOG dimer [mitochondrial matrix]
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9915438] May, Bruce, 2024-07-07
edited	[InstanceEdit:9915443] May, Bruce, 2024-07-07
input	[Complex:9915441] RNA dinucleotide:nascent L strand:mitochondrial genome:RNA dinucleotide:nascent H strand DNA [mitochondrial matrix] [Homo sapiens]
internalReviewed	[InstanceEdit:9918580] D'Eustachio, Peter, 2024-08-17
isChimeric	FALSE
literatureReference	[LiteratureReference:9914860] A unique exonuclease ExoG cleaves between RNA and DNA in mitochondrial DNA replication [LiteratureReference:9914862] EXOG, a novel paralog of Endonuclease G in higher eukaryotes [LiteratureReference:9914988] In vitro reconstitution reveals a key role of human mitochondrial EXOG in RNA primer processing
modified	[InstanceEdit:9916078] May, Bruce, 2024-07-21 [InstanceEdit:9918581] May, Bruce, 2024-08-17 [InstanceEdit:9925847] May, Bruce, 2024-10-27 [InstanceEdit:9925851] May, Bruce, 2024-10-27
name	EXOG cleaves RNA dinucleotide from nascent mitochondrial DNA
output	[Complex:9915450] nascent L strand:mitochondrial genome:nascent H strand [mitochondrial matrix] [Homo sapiens]
precedingEvent	[Reaction:9915449] RNASEH1 cleaves RNA primer from nascent L strand, leaving RNA dinucleotides [Homo sapiens] [BlackBoxEvent:9914858] RNASEH1 cleaves RNA primer from nascent H strand, leaving RNA dinucleotides [Homo sapiens] [BlackBoxEvent:9914858] RNASEH1 cleaves RNA primer from nascent H strand, leaving RNA dinucleotides [Homo sapiens] [BlackBoxEvent:9914498] POLG in the replisome polymerizes the L strand [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2024-12-04
reviewed	[InstanceEdit:9925848] Wu, Chyuan-Chuan, 2024-10-27
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9915456] R-HSA-9915442.1
structureModified	[InstanceEdit:9925847] May, Bruce, 2024-10-27
summation	[Summation:9916077] The RNA primers that initiate the synthesis of mitochondrial...
(hasEvent)	[Pathway:9913635] Strand-asynchronous mitochondrial DNA replication [Homo sapiens]
(precedingEvent)	[Reaction:9914903] LIG3 (Ligase III) ligates nascent mitochondrial DNA strands [Homo sapiens]
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No pathways have been reviewed or authored by EXOG cleaves RNA dinucleotide from nascent mitochondrial DNA (9915442)