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Details on Person UniProt:Q9Y248 GINS2
| Class:Id | ReferenceGeneProduct:99147 |
|---|---|
| _chainChangeLog | chain:1-185 added on Fri February 6 2015 |
| _displayName | UniProt:Q9Y248 GINS2 |
| _timestamp | 2026-02-20 22:14:45 |
| chain | chain:1-185 |
| checksum | 4F6A18B1ED76F93C |
| comment | FUNCTION Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks (PubMed:17417653). GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232).SUBUNIT Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4 (PubMed:17417653, PubMed:17545466, PubMed:17557111, PubMed:17652513, PubMed:32453425). Forms a stable subcomplex with GINS3. GINS complex interacts with DNA primase in vitro (PubMed:17417653, PubMed:17545466, PubMed:17557111, PubMed:17652513). Component of the CMG helicase complex, a hexameric ring of related MCM2-7 subunits stabilized by CDC45 and the tetrameric GINS complex (PubMed:32453425, PubMed:34694004, PubMed:34700328).SUBCELLULAR LOCATION Associates with chromatin.MASS SPECTROMETRY This is the measured mass for the GINS complex.SIMILARITY Belongs to the GINS2/PSF2 family. |
| description | recommendedName: DNA replication complex GINS protein PSF2 alternativeName: GINS complex subunit 2 |
| geneName | GINS2 PSF2 CGI-122 DC5 HSPC037 |
| identifier | Q9Y248 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Chromosome DNA replication Isopeptide bond Nucleus Phosphoprotein Proteomics identification Reference proteome Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | GINS2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8995064] ENSEMBL:ENSG00000131153 GINS2 [Homo sapiens] |
| secondaryIdentifier | PSF2_HUMAN D3DUM5 Q6IAG9 |
| sequenceLength | 185 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:176975] GINS2 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9Y248 GINS2 (99147)
