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Details on Person POLG in the replisome polymerizes the L strand
Class:Id BlackBoxEvent:9914498 _displayName POLG in the replisome polymerizes the L strand _doRelease TRUE _timestamp 2024-10-27 06:08:40 authored [InstanceEdit:9914490] May, Bruce, 2024-06-17 catalystActivity [CatalystActivity:9914384] DNA-directed DNA polymerase activity of L strand primer:Mitochondrial L strand replisome:Mitochondrial H strand replisome:H strand RNA primer:nascent H strand DNA [mitochondrial matrix] compartment [Compartment:5460] mitochondrial matrix created [InstanceEdit:9914421] May, Bruce, 2024-06-24 edited [InstanceEdit:9914490] May, Bruce, 2024-06-17 goBiologicalProcess [GO_BiologicalProcess:17102] mitochondrial DNA replication input [Complex:9914373] L strand primer:Mitochondrial L strand replisome:Mitochondrial H strand replisome:H strand RNA primer:nascent H strand DNA [mitochondrial matrix] [Homo sapiens] [SimpleEntity:110653] dATP [mitochondrial matrix] [SimpleEntity:110669] dCTP [mitochondrial matrix] [SimpleEntity:110681] dGTP [mitochondrial matrix] [SimpleEntity:110719] dTTP [mitochondrial matrix] internalReviewed [InstanceEdit:9918580] D'Eustachio, Peter, 2024-08-17 isChimeric FALSE literatureReference [LiteratureReference:9914366] Mechanism of transcription initiation and primer generation at the mitochondrial replication origin OriL [LiteratureReference:9914993] A novel processive mechanism for DNA synthesis revealed by structure, modeling and mutagenesis of the accessory subunit of human mitochondrial DNA polymerase [LiteratureReference:9914472] Human mitochondrial RNA polymerase primes lagging-strand DNA synthesis in vitro modified [InstanceEdit:9914994] May, Bruce, 2024-07-01 [InstanceEdit:9915595] May, Bruce, 2024-07-12 [InstanceEdit:9915761] May, Bruce, 2024-07-14 [InstanceEdit:9918581] May, Bruce, 2024-08-17 [InstanceEdit:9925847] May, Bruce, 2024-10-27 [InstanceEdit:9925851] May, Bruce, 2024-10-27 name POLG in the replisome polymerizes the L strand output [Complex:9914413] L strand RNA primer:nascent L strand DNA:Mitochondrial L strand replisome:Mitochondrial H strand replisome:H strand RNA primer:nascent H strand DNA [mitochondrial matrix] [Homo sapiens] [SimpleEntity:159450] PPi [mitochondrial matrix] precedingEvent
previousReviewStatus [ReviewStatus:9821383] three stars releaseDate 2024-12-04 reviewed [InstanceEdit:9925848] Wu, Chyuan-Chuan, 2024-10-27 reviewStatus [ReviewStatus:9821382] five stars species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:9914510] R-HSA-9914498.1 structureModified [InstanceEdit:9915761] May, Bruce, 2024-07-14 [InstanceEdit:9925847] May, Bruce, 2024-10-27 summation [Summation:9915725] POLG:POLG2 (POLgamma) initiates polymerization of L strand D... (hasEvent) [Pathway:9913635] Strand-asynchronous mitochondrial DNA replication [Homo sapiens] (precedingEvent) [BlackBoxEvent:9914858] RNASEH1 cleaves RNA primer from nascent H strand, leaving RNA dinucleotides [Homo sapiens]
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No pathways have been reviewed or authored by POLG in the replisome polymerizes the L strand (9914498)
