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Details on Person SSBP1 binds the displaced parental H strand
Class:Id Reaction:9914478
_displayName SSBP1 binds the displaced parental H strand
_doRelease TRUE
_timestamp 2024-10-27 06:11:03
authored [InstanceEdit:9914490] May, Bruce, 2024-06-17
compartment [Compartment:5460] mitochondrial matrix
created [InstanceEdit:9914421] May, Bruce, 2024-06-24
edited [InstanceEdit:9914490] May, Bruce, 2024-06-17
input [Complex:9914429] Mitochondrial H strand replisome:H strand RNA primer:nascent H strand DNA [mitochondrial matrix] [Homo sapiens] [Complex:9913648] SSBP1 tetramer [mitochondrial matrix] [Homo sapiens]
internalReviewed [InstanceEdit:9918580] D'Eustachio, Peter, 2024-08-17
isChimeric FALSE
literatureReference [LiteratureReference:9914419] In vivo occupancy of mitochondrial single-stranded DNA binding protein supports the strand displacement mode of DNA replication [LiteratureReference:9914987] Mechanism of strand displacement DNA synthesis by the coordinated activities of human mitochondrial DNA polymerase and SSB [LiteratureReference:9914967] Analysis of Mitochondrial SSB-DNA Complexes and Their Effects on DNA Polymerase γ Activity by Electron Microscopy and Enzymatic Assays [LiteratureReference:9914982] Functional roles of the N- and C-terminal regions of the human mitochondrial single-stranded DNA-binding protein [LiteratureReference:9914974] Reduced stimulation of recombinant DNA polymerase γ and mitochondrial DNA (mtDNA) helicase by variants of mitochondrial single-stranded DNA-binding protein (mtSSB) correlates with defects in mtDNA replication in animal cells [LiteratureReference:9914985] Using Atomic Force Microscopy to Study the Real Time Dynamics of DNA Unwinding by Mitochondrial Twinkle Helicase [LiteratureReference:9914948] Single-molecule DREEM imaging reveals DNA wrapping around human mitochondrial single-stranded DNA binding protein [LiteratureReference:9914946] The human mitochondrial single-stranded DNA-binding protein displays distinct kinetics and thermodynamics of DNA binding and exchange
modified [InstanceEdit:9914994] May, Bruce, 2024-07-01 [InstanceEdit:9918581] May, Bruce, 2024-08-17 [InstanceEdit:9925851] May, Bruce, 2024-10-27
name SSBP1 binds the displaced parental H strand
output [Complex:9914497] SSBP1:Mitochondrial H strand replisome:H strand RNA primer:nascent H strand [mitochondrial matrix] [Homo sapiens]
precedingEvent
previousReviewStatus [ReviewStatus:9821383] three stars
releaseDate 2024-12-04
reviewed [InstanceEdit:9925848] Wu, Chyuan-Chuan, 2024-10-27
reviewStatus [ReviewStatus:9821382] five stars
species [Species:48887] Homo sapiens
stableIdentifier [StableIdentifier:9914515] R-HSA-9914478.1
summation [Summation:9914959] As POLG:POLG2 in the replisome polymerizes the nascent H str...
(hasEvent) [Pathway:9913635] Strand-asynchronous mitochondrial DNA replication [Homo sapiens]
(precedingEvent) [Reaction:9914404] POLRMT and POLG bind the mitochondrial L strand replication origin (OriL) [Homo sapiens]
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No pathways have been reviewed or authored by SSBP1 binds the displaced parental H strand (9914478)