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Details on Person POLRMT polymerizes RNA primer for mitochondrial L strand replication

Class:Id	BlackBoxEvent:9914409
_displayName	POLRMT polymerizes RNA primer for mitochondrial L strand replication
_doRelease	TRUE
_timestamp	2024-10-27 06:09:53
authored	[InstanceEdit:9914490] May, Bruce, 2024-06-17
catalystActivity	[CatalystActivity:9914369] DNA-directed RNA polymerase activity of POLRMT:POLG:PEO1:OriL:Mitochondrial H strand replisome:H strand RNA primer:nascent H strand DNA [mitochondrial matrix]
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9914421] May, Bruce, 2024-06-24
edited	[InstanceEdit:9914490] May, Bruce, 2024-06-17
input	[Complex:9914388] POLRMT:POLG:PEO1:OriL:Mitochondrial H strand replisome:H strand RNA primer:nascent H strand DNA [mitochondrial matrix] [Homo sapiens] [SimpleEntity:113593] ATP [mitochondrial matrix] [SimpleEntity:110577] CTP [mitochondrial matrix] [SimpleEntity:113573] GTP [mitochondrial matrix] [SimpleEntity:110731] UTP [mitochondrial matrix]
internalReviewed	[InstanceEdit:9918580] D'Eustachio, Peter, 2024-08-17
isChimeric	FALSE
literatureReference	[LiteratureReference:9914477] Mitochondrial RNA polymerase is needed for activation of the origin of light-strand DNA replication [LiteratureReference:9914366] Mechanism of transcription initiation and primer generation at the mitochondrial replication origin OriL [LiteratureReference:9914472] Human mitochondrial RNA polymerase primes lagging-strand DNA synthesis in vitro
modified	[InstanceEdit:9915761] May, Bruce, 2024-07-14 [InstanceEdit:9918581] May, Bruce, 2024-08-17 [InstanceEdit:9925847] May, Bruce, 2024-10-27 [InstanceEdit:9925851] May, Bruce, 2024-10-27
name	POLRMT polymerizes RNA primer for mitochondrial L strand replication
output	[EntityWithAccessionedSequence:163267] POLRMT [mitochondrial matrix] [Homo sapiens] [Complex:9914373] L strand primer:Mitochondrial L strand replisome:Mitochondrial H strand replisome:H strand RNA primer:nascent H strand DNA [mitochondrial matrix] [Homo sapiens] [SimpleEntity:159450] PPi [mitochondrial matrix]
precedingEvent	[Reaction:9914404] POLRMT and POLG bind the mitochondrial L strand replication origin (OriL) [Homo sapiens] [Reaction:9914478] SSBP1 binds the displaced parental H strand [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2024-12-04
reviewed	[InstanceEdit:9925848] Wu, Chyuan-Chuan, 2024-10-27
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9914523] R-HSA-9914409.1
structureModified	[InstanceEdit:9915761] May, Bruce, 2024-07-14 [InstanceEdit:9925847] May, Bruce, 2024-10-27
summation	[Summation:9915752] POLRMT initiates transcription at a stem-loop structure in O...
(hasEvent)	[Pathway:9913635] Strand-asynchronous mitochondrial DNA replication [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9914498] POLG in the replisome polymerizes the L strand [Homo sapiens] [NegativePrecedingEvent:9916965] Incorrect Order: POLRMT polymerizes RNA primer for mitochondrial L strand replication
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No pathways have been reviewed or authored by POLRMT polymerizes RNA primer for mitochondrial L strand replication (9914409)