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Details on Person MdtE:MdtF:TolC exports beta-lactams to extracellular space

Class:Id	Reaction:9914083
_displayName	MdtE:MdtF:TolC exports beta-lactams to extracellular space
_doRelease	TRUE
_timestamp	2025-05-21 07:44:53
authored	[InstanceEdit:9914081] Stephan, Ralf, 2024-06-20
catalystActivity	[CatalystActivity:9914077] porin activity of MdtE:MdtF:TolC [cell outer membrane]
compartment	[Compartment:1222638] periplasmic space [Compartment:20798] cell outer membrane [Compartment:984] extracellular region
created	[InstanceEdit:9914076] Stephan, Ralf, 2024-06-20
disease	[Disease:3134792] bacterial infectious disease
edited	[InstanceEdit:9948470] Stephan, Ralf, 2025-05-21
input	[DefinedSet:9913950] β-lactam antibiotics [periplasmic space]
internalReviewed	[InstanceEdit:9915005] Gillespie, Marc E, 2024-07-02 [InstanceEdit:9917579] Gillespie, Marc E, 2024-08-08
isChimeric	FALSE
literatureReference	[LiteratureReference:9914074] Roles of TolC-dependent multidrug transporters of Escherichia coli in resistance to beta-lactams [LiteratureReference:9639435] AcrA is a highly asymmetric protein capable of spanning the periplasm [LiteratureReference:9911303] RND transporters in the living world [LiteratureReference:9911195] Structure, Assembly, and Function of Tripartite Efflux and Type 1 Secretion Systems in Gram-Negative Bacteria
modified	[InstanceEdit:9915006] Stephan, Ralf, 2024-07-02 [InstanceEdit:9915160] Stephan, Ralf, 2024-07-03 [InstanceEdit:9917580] Stephan, Ralf, 2024-08-08 [InstanceEdit:9931098] Stephan, Ralf, 2024-12-10 [InstanceEdit:9933047] Stephan, Ralf, 2024-12-23 [InstanceEdit:9939561] Stephan, Ralf, 2025-02-28 [InstanceEdit:9948469] Stephan, Ralf, 2025-05-21
name	MdtE:MdtF:TolC exports beta-lactams to extracellular space
output	[DefinedSet:9913955] β-lactam antibiotics [extracellular region]
precedingEvent	[Reaction:9914089] MdtE:MdtF:TolC exports beta-lactams to the periplasm [Homo sapiens] [Reaction:9911512] AcrA:AcrB:TolC transports antibiotics from the cytosol to the periplasm [Homo sapiens]
relatedSpecies	[Species:159879] Escherichia coli
releaseDate	2025-06-18
reviewStatus	[ReviewStatus:9821383] three stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9914094] R-HSA-9914083.1
summation	[Summation:9914079] The MdtE/MdtF (aka MdtEF or YhiUV) transporter complex in th...
(hasEvent)	[Pathway:9913143] Antimicrobial resistance [Homo sapiens]
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No pathways have been reviewed or authored by MdtE:MdtF:TolC exports beta-lactams to extracellular space (9914083)