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Details on Person UniProt:P37637 mdtF
| Class:Id | ReferenceGeneProduct:9914078 |
|---|---|
| _chainChangeLog | chain:1-1037 for 9914078 added on Fri Aug 09 2024 |
| _displayName | UniProt:P37637 mdtF |
| _timestamp | 2026-02-20 22:45:42 |
| chain | chain:1-1037 |
| checksum | 3B67502160F51724 |
| comment | FUNCTION Part of the tripartite efflux system MdtEF-TolC, which confers resistance to compounds such as rhodamine 6G, erythromycin, doxorubicin, ethidium bromide, TPP, SDS, deoxycholate, crystal violet and benzalkonium.SUBUNIT Homotrimer. Part of the tripartite efflux system MdtEF-TolC, which is composed of an inner membrane transporter, MdtF, a membrane fusion protein, MdtE, and an outer membrane component, TolC. The complex forms a large protein conduit and can translocate molecules across both the inner and outer membranes.SUBCELLULAR LOCATION Induced by EvgA, probably via YdeO.SIMILARITY Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. |
| created | [InstanceEdit:9914076] Stephan, Ralf, 2024-06-20 |
| description | recommendedName: Multidrug resistance protein MdtF |
| geneName | mdtF yhiV b3514 JW3482 |
| identifier | P37637 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Antibiotic resistance Cell inner membrane Cell membrane Membrane Reference proteome Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | mdtF |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | MDTF_ECOLI Q2M7H6 |
| sequenceLength | 1037 |
| species | [Species:159879] Escherichia coli |
| (referenceEntity) | [EntityWithAccessionedSequence:9914075] MdtF [plasma membrane] [Escherichia coli] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P37637 mdtF (9914078)
