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Details on Person Diagram of Meiotic recombination

Class:IdPathwayDiagram:991376
_displayNameDiagram of Meiotic recombination
_timestamp2024-04-25 21:41:32
created[InstanceEdit:991377] May, B, 2010-11-04
height1621
modified[InstanceEdit:1216534] May, B, 2011-02-15
[InstanceEdit:1221664] May, B, 2011-02-26
[InstanceEdit:2394021] May, B, 2012-06-28
[InstanceEdit:5255525] May, B, 2014-02-06
[InstanceEdit:5391589] May, Bruce, 2014-04-30
[InstanceEdit:9023950] May, Bruce, 2017-09-29
[InstanceEdit:9853883] Orlic-Milacic, Marija, 2023-11-21
[InstanceEdit:9909061] Orlic-Milacic, Marija, 2024-04-25
representedPathway[Pathway:912446] Meiotic recombination [Homo sapiens]
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</org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="58" reactomeId="912490" position="157 755" bounds="120 740 74 30" textPosition="135 744"> <Properties> <displayName>DMC1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="59" reactomeId="975775" position="238 578" bounds="127 564 222 29" textPosition="175 571" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>H2AFX-Nucleosome</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="60" reactomeId="912507" position="294 879" bounds="165 866 258 26" textPosition="178 870" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Meiotic single-stranded DNA complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="61" reactomeId="217039" position="424 766" bounds="376 749 96 35" textPosition="395 755"> <Properties> 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<Properties> <displayName>DNA</displayName> </Properties> </org.gk.render.RenderableEntity> <org.gk.render.RenderableProtein id="72" reactomeId="912435" position="569 1111" bounds="525 1099 88 25" textPosition="547 1100"> <Properties> <displayName>MSH5</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="73" reactomeId="912455" position="566 1171" bounds="527 1158 78 27" textPosition="544 1160"> <Properties> <displayName>MSH4</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="74" reactomeId="912452" position="568 1219" bounds="526 1205 84 29" textPosition="544 1208"> <Properties> <displayName>TOP3A</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="75" reactomeId="174881" position="570 1265" bounds="529 1252 83 26" textPosition="554 1254"> <Properties> <displayName>BLM</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="76" reactomeId="912428" position="300 1364" bounds="201 1352 198 24" textPosition="222 1354" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Meiotic Holliday Junction</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="78" reactomeId="912495" position="302 1417" bounds="265 1404 75 27" textPosition="281 1406"> <Properties> <displayName>MLH1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="79" reactomeId="912478" position="520 1320" bounds="473 1309 94 23" textPosition="499 1309"> <Properties> <displayName>MLH3</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="80" reactomeId="68365" position="480 1358" bounds="440 1348 80 20" textPosition="459 1347"> <Properties> <displayName>CDK2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex 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H3K4me3</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="86" reactomeId="77502" position="835 306" bounds="763 291 144 31" textPosition="807 295"> <Properties> <displayName>AdoHcy</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="88" reactomeId="9023945" position="326 369" bounds="225 350 203 39" textPosition="225 353" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SPO11:double strand break with 3' single strand breaks</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="98" reactomeId="9853380" position="153 930" bounds="122 913 63 35" textPosition="128 912" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>FIRRM:FIGNL1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="99" reactomeId="9853879" position="123 1100" bounds="73 1082 100 36" textPosition="75 1082" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableEntitySet id="104" reactomeId="9909058" position="109 879" bounds="76 863 66 33" textPosition="83 862" /> </Nodes> <Edges> <org.gk.render.RenderableReaction id="19" reactomeId="912363" points="578 163, 578 177, 579 224" position="578 177" lineWidth="1.0"> <Inputs> <Input id="20" points="385 91" /> <Input id="21" points="580 111" /> </Inputs> <Outputs> <Output id="22" /> </Outputs> <Properties> <displayName>PRDM9 binds recombination hotspot motifs in DNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="23" reactomeId="912368" points="323 166, 323 217, 323 248" position="323 217" lineWidth="1.0"> <Inputs> <Input id="20" points="354 91" /> <Input id="24" points="249 128" /> </Inputs> <Outputs> <Output id="25" /> </Outputs> <Catalysts> <Catalyst id="24" points="238 128" /> </Catalysts> <Properties> <displayName>SPO11 hydrolyzes DNA forming double-strand breaks</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="52" reactomeId="912503" points="295 696, 291 772, 293 863" position="291 772" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="53" points="139 695" /> <Input id="41" points="578 588" /> <Input id="54" points="609 673" /> <Input id="55" points="590 720" /> <Input id="56" points="197 643" /> <Input id="57" points="636 623" /> <Input id="38" points="434 534" /> <Input id="58" points="192 737" /> <Input id="59" points="245 596" /> </Inputs> <Outputs> <Output id="60" /> </Outputs> <Activators> <Activator id="61" points="373 768" /> <Activator id="62" points="380 803" /> </Activators> <Properties> <displayName>Formation of meiotic single-stranded DNA invasion complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="64" reactomeId="912458" points="272 961, 298 1016, 300 1079" position="298 1016" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="60" points="290 895" /> <Input id="68" points="191 968, 241 943" /> </Inputs> <Outputs> <Output id="65" /> </Outputs> <Catalysts> <Catalyst id="60" points="294 895" /> </Catalysts> <Activators> <Activator id="66" points="423 989" /> </Activators> <Properties> <displayName>Formation of meiotic heteroduplex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="71" reactomeId="912496" points="306 1221, 303 1267, 302 1305" position="303 1267" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="72" points="539 1127" /> <Input id="73" points="524 1178" /> <Input id="74" points="523 1219" /> <Input id="75" points="526 1258" /> <Input id="65" points="301 1109" /> </Inputs> <Outputs> <Output id="53" points="73 716, 27 767, 29 1182" /> <Output id="76" points="300 1349" /> <Output id="58" points="143 773, 51 872, 48 1163" /> </Outputs> <Properties> <displayName>Formation of meiotic holliday junction</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="77" reactomeId="912429" points="576 1436, 644 1435, 763 1473" position="644 1435" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="78" points="343 1419" /> <Input id="76" points="346 1379" /> <Input id="79" points="525 1335" /> <Input id="80" points="492 1371" /> </Inputs> <Outputs> <Output id="72" points="616 1122, 676 1138" /> <Output id="73" points="608 1178, 665 1191" /> <Output id="74" points="613 1230, 658 1243" /> <Output id="75" points="615 1273, 649 1282" /> <Output id="54" points="715 690, 742 696" /> <Output id="55" points="679 745, 712 756" /> <Output id="57" points="719 634, 773 660" /> <Output id="81" points="765 1540" /> </Outputs> <Properties> <displayName>Resolution of meiotic holliday junction</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="82" reactomeId="1214188" points="693 238, 692 261, 693 282" position="692 261" lineWidth="1.0"> <Inputs> <Input id="83" points="698 169" /> <Input id="84" stoichiometry="2" points="775 217" /> </Inputs> <Outputs> <Output id="85" points="691 343" /> <Output id="86" stoichiometry="2" points="760 293" /> </Outputs> <Catalysts> <Catalyst id="22" points="629 249" /> </Catalysts> <Properties> <displayName>PRDM9 trimethylates histone H3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="87" reactomeId="9023941" points="323 278, 322 318, 324 347" position="322 318" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="25" /> </Inputs> <Outputs> <Output id="88" /> </Outputs> <Catalysts> <Catalyst id="39" points="163 354" /> </Catalysts> <Properties> <displayName>MRN:CtIP endonucleolytically cleaves single-strand DNA 3' to SPO11</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="89" 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