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Details on Person OqxA exports fluoroquinolones

Class:IdReaction:9913672
_displayNameOqxA exports fluoroquinolones
_doReleaseTRUE
_timestamp2025-05-21 07:45:47
authored[InstanceEdit:9913673] Stephan, Ralf, 2024-06-17
catalystActivity[CatalystActivity:9913669] xenobiotic transmembrane transporter activity of OqxA [plasma membrane]
compartment[Compartment:876] plasma membrane
[Compartment:70101] cytosol
[Compartment:1222638] periplasmic space
created[InstanceEdit:9913677] Stephan, Ralf, 2024-06-17
disease[Disease:3134792] bacterial infectious disease
edited[InstanceEdit:9948470] Stephan, Ralf, 2025-05-21
input[DefinedSet:9912557] Fluoroquinolone antibiotics [cytosol]
[SimpleEntity:8858135] H+ [periplasmic space]
internalReviewed[InstanceEdit:9915005] Gillespie, Marc E, 2024-07-02
[InstanceEdit:9917579] Gillespie, Marc E, 2024-08-08
isChimericFALSE
literatureReference[LiteratureReference:9911303] RND transporters in the living world
[LiteratureReference:9913140] The resistance mechanisms of bacteria against ciprofloxacin and new approaches for enhancing the efficacy of this antibiotic
[LiteratureReference:9913434] Transferable mechanisms of quinolone resistance
[LiteratureReference:9913681] Plasmid-encoded multidrug efflux pump conferring resistance to olaquindox in Escherichia coli
[LiteratureReference:9913676] Substrate specificity of the OqxAB multidrug resistance pump in Escherichia coli and selected enteric bacteria
modified[InstanceEdit:9914259] Stephan, Ralf, 2024-06-23
[InstanceEdit:9915003] Stephan, Ralf, 2024-07-01
[InstanceEdit:9915006] Stephan, Ralf, 2024-07-02
[InstanceEdit:9915160] Stephan, Ralf, 2024-07-03
[InstanceEdit:9917580] Stephan, Ralf, 2024-08-08
[InstanceEdit:9931098] Stephan, Ralf, 2024-12-10
[InstanceEdit:9933047] Stephan, Ralf, 2024-12-23
[InstanceEdit:9948469] Stephan, Ralf, 2025-05-21
nameOqxA exports fluoroquinolones
output[DefinedSet:9913444] Fluoroquinolone antibiotics [periplasmic space]
[SimpleEntity:70106] H+ [cytosol]
relatedSpecies[Species:159879] Escherichia coli
releaseDate2025-06-18
reviewStatus[ReviewStatus:9821383] three stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9913683] R-HSA-9913672.1
summation[Summation:9913667] OqxA is a transport protein of the Resistance-Nodulation-Cel...
(hasEvent)[Pathway:9913143] Antimicrobial resistance [Homo sapiens]
(precedingEvent)[Reaction:9911516] AcrA:AcrB:TolC transports antibiotics from the periplasm to the extracellular region [Homo sapiens]
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No pathways have been reviewed or authored by OqxA exports fluoroquinolones (9913672)
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