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Details on Person RNASEH1 cleaves R-loop RNA to yield RNA primer for H strand polymerization

Class:Id	Reaction:9913637
_displayName	RNASEH1 cleaves R-loop RNA to yield RNA primer for H strand polymerization
_doRelease	TRUE
_timestamp	2024-10-27 06:10:11
authored	[InstanceEdit:9913627] May, Bruce, 2024-06-15
catalystActivity	[CatalystActivity:9913641] RNA-DNA hybrid ribonuclease activity of RNASEH1:Mg2+ [mitochondrial matrix]
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9913621] May, Bruce, 2024-06-16
edited	[InstanceEdit:9913627] May, Bruce, 2024-06-15
input	[Complex:9913623] R-loop RNA:mitochondrial genome [mitochondrial matrix] [Homo sapiens]
internalReviewed	[InstanceEdit:9918580] D'Eustachio, Peter, 2024-08-17
isChimeric	FALSE
literatureReference	[LiteratureReference:9913616] RNase H1 directs origin-specific initiation of DNA replication in human mitochondria [LiteratureReference:9914395] Mammalian RNase H1 directs RNA primer formation for mtDNA replication initiation and is also necessary for mtDNA replication completion [LiteratureReference:9913647] Priming of human mitochondrial DNA replication occurs at the light-strand promoter [LiteratureReference:9914403] A hybrid G-quadruplex structure formed between RNA and DNA explains the extraordinary stability of the mitochondrial R-loop [LiteratureReference:9914890] In vivo determination of replication origins of human mitochondrial DNA by ligation-mediated polymerase chain reaction [LiteratureReference:9914923] Conserved sequence box II directs transcription termination and primer formation in mitochondria
modified	[InstanceEdit:9914526] May, Bruce, 2024-06-24 [InstanceEdit:9914943] May, Bruce, 2024-06-30 [InstanceEdit:9915463] May, Bruce, 2024-07-07 [InstanceEdit:9915761] May, Bruce, 2024-07-14 [InstanceEdit:9918581] May, Bruce, 2024-08-17 [InstanceEdit:9925851] May, Bruce, 2024-10-27
name	RNASEH1 cleaves R-loop RNA to yield RNA primer for H strand polymerization
output	[Complex:9913633] H strand RNA primer:Mitochondrial genome [mitochondrial matrix] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9915448] POLRMT polymerizes R-loop RNA [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2024-12-04
requiredInputComponent	[Complex:9913648] SSBP1 tetramer [mitochondrial matrix] [Homo sapiens]
reviewed	[InstanceEdit:9925848] Wu, Chyuan-Chuan, 2024-10-27
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9913663] R-HSA-9913637.1
structureModified	[InstanceEdit:9914526] May, Bruce, 2024-06-24
summation	[Summation:9914430] The mitochondrial RNA polymerase POLRMT synthesizes an RNA o...
(hasEvent)	[Pathway:9913635] Strand-asynchronous mitochondrial DNA replication [Homo sapiens]
(precedingEvent)	[Reaction:9913634] POLG:POLG2 and TWNK (PEO1) bind mitochondrial DNA:RNA primer to form H strand replisome [Homo sapiens]
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No pathways have been reviewed or authored by RNASEH1 cleaves R-loop RNA to yield RNA primer for H strand polymerization (9913637)