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Details on Person POLG:POLG2 and TWNK (PEO1) bind mitochondrial DNA:RNA primer to form H strand replisome

Class:Id	Reaction:9913634
_displayName	POLG:POLG2 and TWNK (PEO1) bind mitochondrial DNA:RNA primer to form H strand replisome
_doRelease	TRUE
_timestamp	2024-10-27 06:08:58
authored	[InstanceEdit:9913627] May, Bruce, 2024-06-15
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9913621] May, Bruce, 2024-06-16
edited	[InstanceEdit:9913627] May, Bruce, 2024-06-15
input	[Complex:9913633] H strand RNA primer:Mitochondrial genome [mitochondrial matrix] [Homo sapiens] [Complex:9913642] POLG:POLG2 [mitochondrial matrix] [Homo sapiens] [Complex:9913644] TWNK hexamer [mitochondrial matrix] [Homo sapiens]
internalReviewed	[InstanceEdit:9918580] D'Eustachio, Peter, 2024-08-17
isChimeric	FALSE
literatureReference	[LiteratureReference:9913629] Reconstitution of a minimal mtDNA replisome in vitro [LiteratureReference:9914467] Composition and dynamics of human mitochondrial nucleoids [LiteratureReference:9914415] The mitochondrial DNA helicase TWINKLE can assemble on a closed circular template and support initiation of DNA synthesis [LiteratureReference:9914392] Regulation of DNA replication at the end of the mitochondrial D-loop involves the helicase TWINKLE and a conserved sequence element [LiteratureReference:9914972] Single-molecule level structural dynamics of DNA unwinding by human mitochondrial Twinkle helicase [LiteratureReference:9914985] Using Atomic Force Microscopy to Study the Real Time Dynamics of DNA Unwinding by Mitochondrial Twinkle Helicase
modified	[InstanceEdit:9914526] May, Bruce, 2024-06-24 [InstanceEdit:9915761] May, Bruce, 2024-07-14 [InstanceEdit:9916928] May, Bruce, 2024-07-27 [InstanceEdit:9918581] May, Bruce, 2024-08-17 [InstanceEdit:9925851] May, Bruce, 2024-10-27
name	POLG:POLG2 and TWNK (PEO1) bind mitochondrial DNA:RNA primer to form H strand replisome
output	[Complex:9913617] Mitochondrial H strand replisome [mitochondrial matrix] [Homo sapiens]
precedingEvent	[Reaction:9913637] RNASEH1 cleaves R-loop RNA to yield RNA primer for H strand polymerization [Homo sapiens] [BlackBoxEvent:9915448] POLRMT polymerizes R-loop RNA [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2024-12-04
reviewed	[InstanceEdit:9925848] Wu, Chyuan-Chuan, 2024-10-27
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9913649] R-HSA-9913634.1
structureModified	[InstanceEdit:9914526] May, Bruce, 2024-06-24 [InstanceEdit:9915761] May, Bruce, 2024-07-14
summation	[Summation:9914390] The DNA helicase TWINKLE (TWNK, PEO1) and the DNA polymerase...
(hasEvent)	[Pathway:9913635] Strand-asynchronous mitochondrial DNA replication [Homo sapiens]
(precedingEvent)	[Reaction:9914438] TWNK (PEO1) unwinds double-stranded mitochondrial DNA at the replication fork [Homo sapiens]
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No pathways have been reviewed or authored by POLG:POLG2 and TWNK (PEO1) bind mitochondrial DNA:RNA primer to form H strand replisome (9913634)