Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Pef exports fluoroquinolones

Class:IdReaction:9913437
_displayNamePef exports fluoroquinolones
_doReleaseTRUE
_timestamp2025-05-21 07:46:13
authored[InstanceEdit:9913427] Stephan, Ralf, 2024-06-14
catalystActivity[CatalystActivity:9913432] xenobiotic transmembrane transporter activity of Pef [plasma membrane]
compartment[Compartment:876] plasma membrane
[Compartment:70101] cytosol
[Compartment:1222638] periplasmic space
created[InstanceEdit:9913448] Stephan, Ralf, 2024-06-14
disease[Disease:3134792] bacterial infectious disease
edited[InstanceEdit:9948470] Stephan, Ralf, 2025-05-21
input[DefinedSet:9912557] Fluoroquinolone antibiotics [cytosol]
[SimpleEntity:8858135] H+ [periplasmic space]
internalReviewed[InstanceEdit:9915005] Gillespie, Marc E, 2024-07-02
[InstanceEdit:9917579] Gillespie, Marc E, 2024-08-08
isChimericFALSE
literatureReference[LiteratureReference:9913140] The resistance mechanisms of bacteria against ciprofloxacin and new approaches for enhancing the efficacy of this antibiotic
[LiteratureReference:9913434] Transferable mechanisms of quinolone resistance
[LiteratureReference:9913450] New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate
[LiteratureReference:9913439] Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli
modified[InstanceEdit:9914259] Stephan, Ralf, 2024-06-23
[InstanceEdit:9915003] Stephan, Ralf, 2024-07-01
[InstanceEdit:9915006] Stephan, Ralf, 2024-07-02
[InstanceEdit:9915160] Stephan, Ralf, 2024-07-03
[InstanceEdit:9917580] Stephan, Ralf, 2024-08-08
[InstanceEdit:9931098] Stephan, Ralf, 2024-12-10
[InstanceEdit:9933047] Stephan, Ralf, 2024-12-23
[InstanceEdit:9948469] Stephan, Ralf, 2025-05-21
namePef exports fluoroquinolones
output[DefinedSet:9913444] Fluoroquinolone antibiotics [periplasmic space]
[SimpleEntity:70106] H+ [cytosol]
relatedSpecies[Species:159879] Escherichia coli
releaseDate2025-06-18
reviewStatus[ReviewStatus:9821383] three stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9913453] R-HSA-9913437.1
summation[Summation:9913433] pef (aka qepA)-like genes, coding for transport proteins of ...
(hasEvent)[Pathway:9913143] Antimicrobial resistance [Homo sapiens]
(precedingEvent)[Reaction:9911516] AcrA:AcrB:TolC transports antibiotics from the periplasm to the extracellular region [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by Pef exports fluoroquinolones (9913437)
Follow Reactome