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Details on Person AAC(6′)-Ib acetylates ciprofloxacin

Class:Id	Reaction:9913373
_displayName	AAC(6′)-Ib acetylates ciprofloxacin
_doRelease	TRUE
_timestamp	2025-05-21 07:36:38
authored	[InstanceEdit:9913368] Stephan, Ralf, 2024-06-13
catalystActivity	[CatalystActivity:9913372] N-acetyltransferase activity of AAC(6')-Ib [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9913378] Stephan, Ralf, 2024-06-13
disease	[Disease:3134792] bacterial infectious disease
edited	[InstanceEdit:9948470] Stephan, Ralf, 2025-05-21
input	[ChemicalDrug:9912554] ciprofloxacin [cytosol] [SimpleEntity:76183] Ac-CoA [cytosol]
internalReviewed	[InstanceEdit:9917579] Gillespie, Marc E, 2024-08-08
isChimeric	FALSE
literatureReference	[LiteratureReference:9913366] Mechanistic and structural analysis of aminoglycoside N-acetyltransferase AAC(6')-Ib and its bifunctional, fluoroquinolone-active AAC(6')-Ib-cr variant [LiteratureReference:9913367] Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase [LiteratureReference:9913434] Transferable mechanisms of quinolone resistance
modified	[InstanceEdit:9913448] Stephan, Ralf, 2024-06-14 [InstanceEdit:9915006] Stephan, Ralf, 2024-07-02 [InstanceEdit:9917580] Stephan, Ralf, 2024-08-08 [InstanceEdit:9931098] Stephan, Ralf, 2024-12-10 [InstanceEdit:9933047] Stephan, Ralf, 2024-12-23 [InstanceEdit:9948469] Stephan, Ralf, 2025-05-21
name	AAC(6′)-Ib acetylates ciprofloxacin
output	[SimpleEntity:9913379] N-acetylciprofloxacin [cytosol] [SimpleEntity:76194] CoA-SH [cytosol] [SimpleEntity:70106] H+ [cytosol]
relatedSpecies	[Species:159879] Escherichia coli
releaseDate	2025-06-18
reviewStatus	[ReviewStatus:9821383] three stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9913380] R-HSA-9913373.1
summation	[Summation:9913370] Many E.coli plasmids contain genes coding for AAC(6′)-Ib whi...
(hasEvent)	[Pathway:9913143] Antimicrobial resistance [Homo sapiens]
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No pathways have been reviewed or authored by AAC(6′)-Ib acetylates ciprofloxacin (9913373)