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Details on Person Fluoroquinolones bind gyrase

Class:IdReaction:9913142
_displayNameFluoroquinolones bind gyrase
_doReleaseTRUE
_timestamp2025-05-21 07:41:57
authored[InstanceEdit:9913149] Stephan, Ralf, 2024-06-12
compartment[Compartment:70101] cytosol
created[InstanceEdit:9913145] Stephan, Ralf, 2024-06-12
disease[Disease:3134792] bacterial infectious disease
edited[InstanceEdit:9948470] Stephan, Ralf, 2025-05-21
input[DefinedSet:9912557] Fluoroquinolone antibiotics [cytosol]
[Complex:9639502] gyrase [cytosol] [Escherichia coli]
internalReviewed[InstanceEdit:9915005] Gillespie, Marc E, 2024-07-02
[InstanceEdit:9917579] Gillespie, Marc E, 2024-08-08
isChimericFALSE
literatureReference[LiteratureReference:9913140] The resistance mechanisms of bacteria against ciprofloxacin and new approaches for enhancing the efficacy of this antibiotic
[LiteratureReference:9913434] Transferable mechanisms of quinolone resistance
modified[InstanceEdit:9913448] Stephan, Ralf, 2024-06-14
[InstanceEdit:9915003] Stephan, Ralf, 2024-07-01
[InstanceEdit:9915006] Stephan, Ralf, 2024-07-02
[InstanceEdit:9917580] Stephan, Ralf, 2024-08-08
[InstanceEdit:9931098] Stephan, Ralf, 2024-12-10
[InstanceEdit:9933047] Stephan, Ralf, 2024-12-23
[InstanceEdit:9948469] Stephan, Ralf, 2025-05-21
nameFluoroquinolones bind gyrase
output[Complex:9913146] Fluoroquinolones:gyrase [cytosol] [Escherichia coli]
regulatedBy[NegativeRegulation:9913153] Negative regulation by 'Qnr:gyrase [cytosol]'
[NegativeRegulation:9913440] Negative regulation by 'N-acetylciprofloxacin [cytosol]'
relatedSpecies[Species:159879] Escherichia coli
releaseDate2025-06-18
reviewStatus[ReviewStatus:9821383] three stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9913156] R-HSA-9913142.1
structureModified[InstanceEdit:9913448] Stephan, Ralf, 2024-06-14
summation[Summation:9913147] The main bactericidal effect of fluoroquinolone antibiotics ...
(hasEvent)[Pathway:9638771] Action of antimicrobials [Homo sapiens]
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No pathways have been reviewed or authored by Fluoroquinolones bind gyrase (9913142)