Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person TetA exports tetracyclines

Class:IdReaction:9913128
_displayNameTetA exports tetracyclines
_doReleaseTRUE
_timestamp2025-05-21 07:47:35
authored[InstanceEdit:9914264] Stephan, Ralf, 2024-06-23
catalystActivity[CatalystActivity:9913124] xenobiotic transmembrane transporter activity of TetA homologs [plasma membrane]
compartment[Compartment:876] plasma membrane
[Compartment:70101] cytosol
[Compartment:1222638] periplasmic space
created[InstanceEdit:9913123] Stephan, Ralf, 2024-06-11
disease[Disease:3134792] bacterial infectious disease
edited[InstanceEdit:9948470] Stephan, Ralf, 2025-05-21
input[SimpleEntity:8858135] H+ [periplasmic space]
[Complex:9913101] tetracyclines:Mg2+ [cytosol]
internalReviewed[InstanceEdit:9915005] Gillespie, Marc E, 2024-07-02
[InstanceEdit:9917579] Gillespie, Marc E, 2024-08-08
isChimericFALSE
literatureReference[LiteratureReference:9913095] Resistance gene patterns of tetracycline resistant Escherichia coli of human and porcine origin
[LiteratureReference:9913100] Substitutions in the interdomain loop of the Tn10 TetA efflux transporter alter tetracycline resistance and substrate specificity
modified[InstanceEdit:9914259] Stephan, Ralf, 2024-06-23
[InstanceEdit:9915006] Stephan, Ralf, 2024-07-02
[InstanceEdit:9915160] Stephan, Ralf, 2024-07-03
[InstanceEdit:9917580] Stephan, Ralf, 2024-08-08
[InstanceEdit:9931098] Stephan, Ralf, 2024-12-10
[InstanceEdit:9933047] Stephan, Ralf, 2024-12-23
[InstanceEdit:9948469] Stephan, Ralf, 2025-05-21
nameTetA exports tetracyclines
output[SimpleEntity:70106] H+ [cytosol]
[Complex:9913110] tetracyclines:Mg2+ [periplasmic space]
relatedSpecies[Species:159879] Escherichia coli
releaseDate2025-06-18
reviewStatus[ReviewStatus:9821383] three stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9913135] R-HSA-9913128.1
summation[Summation:9913129] A common tetracycline resistance gene in human infections wi...
(hasEvent)[Pathway:9913143] Antimicrobial resistance [Homo sapiens]
(precedingEvent)[Reaction:9911516] AcrA:AcrB:TolC transports antibiotics from the periplasm to the extracellular region [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by TetA exports tetracyclines (9913128)