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Details on Person The transcriptional regulation of CD274 (PD-L1/programmed de...
| Class:Id | Summation:9912811 |
|---|---|
| _displayName | The transcriptional regulation of CD274 (PD-L1/programmed de... |
| _timestamp | 2024-06-10 12:28:44 |
| created | [InstanceEdit:9912800] Tiwari, Krishna, 2024-06-10 |
| modified | [InstanceEdit:9912831] Tiwari, Krishna, 2024-06-10 |
| text | The transcriptional regulation of CD274 (PD-L1/programmed death-ligand 1) is crucial in cancer biology, enabling tumor cells to evade immune detection. PD-L1 expression is tightly controlled by various transcription factors and signalling pathways responding to both intrinsic cellular signals and extrinsic environmental perturbations. It is regulated transcriptionally by multiple mechanisms, including epigenetic modifications (EZH2, DNMTs, MLLs) and transcription factors (STAT3, STAT1, IRF1, MYC, HIF, and others) activated by various upstream signalling pathways. The regulation of PD-L1 is a complex interplay of oncogenic signalling pathways, cytokine responses, epigenetic modifications, specific transcription factors, the tumor microenvironment, and non-coding RNAs. This multifaceted regulation finely tunes PD-L1 expression to promote immune evasion in cancer, making it a critical target for cancer immunotherapy (Zhou et al., 2023, Cha et al.,2019, Yamaguchi et al.,2022, Ju et al., 2020). |
| (summation) | [BlackBoxEvent:9909623] CD274 Transcription [Homo sapiens] |
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No pathways have been reviewed or authored by The transcriptional regulation of CD274 (PD-L1/programmed de... (9912811)
