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Details on Person Proteasomal cleavage of partially digested antigen (immunoproteasome catalyst)

Class:Id	BlackBoxEvent:9912751
_displayName	Proteasomal cleavage of partially digested antigen (immunoproteasome catalyst)
_doRelease	TRUE
_timestamp	2025-02-20 18:32:49
authored	[InstanceEdit:9913779] Shamovsky, Veronica, 2024-06-17
catalystActivity	[CatalystActivity:9912612] endopeptidase activity of Immunoproteasome [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9912749] Shamovsky, Veronica, 2024-06-10
edited	[InstanceEdit:9937613] Shamovsky, Veronica, 2025-02-05
input	[OtherEntity:1236718] partially digested Ag [cytosol] [SimpleEntity:29356] H2O [cytosol]
internalReviewed	[InstanceEdit:9913780] Orlic-Milacic, Marija, 2024-06-17
isChimeric	FALSE
literatureReference	[LiteratureReference:9912664] Virus-induced type I IFN stimulates generation of immunoproteasomes at the site of infection [LiteratureReference:9908575] Assembly mechanisms of specialized core particles of the proteasome
modified	[InstanceEdit:9913782] Shamovsky, Veronica, 2024-06-17 [InstanceEdit:9938678] Shamovsky, Veronica, 2025-02-18 [InstanceEdit:9938875] Shamovsky, Veronica, 2025-02-20
name	Proteasomal cleavage of partially digested antigen (immunoproteasome catalyst)
output	[SimpleEntity:8955634] oligopeptide fragment (3-7aa) [cytosol] [SimpleEntity:983032] oligopeptide fragment (8-16aa) [cytosol] [SimpleEntity:983036] precursor peptide fragment (>16 aa) [cytosol]
precedingEvent	[Reaction:1236947] Egress of internalized antigen to the cytosol via sec61 [Homo sapiens] [BlackBoxEvent:1236938] Partial proteolysis of antigen in phagolysosomes [Homo sapiens] [BlackBoxEvent:1236972] Escape of antigens from phagosome to cytosol [Homo sapiens] [BlackBoxEvent:1236938] Partial proteolysis of antigen in phagolysosomes [Homo sapiens] [BlackBoxEvent:9908186] Formation of the immunoproteasome [Homo sapiens] [Reaction:9908686] Formation of the PA28-alpha-beta regulatory particle [Homo sapiens] [BlackBoxEvent:9908105] Maturation of the 20S immunoproteasome core particle [Homo sapiens]
releaseDate	2025-03-26
reviewStatus	[ReviewStatus:9821383] three stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9912752] R-HSA-9912751.1
summation	[Summation:9912750] Proteasomal degradation generates antigenic peptides that ca...
(hasEvent)	[Pathway:1236974] ER-Phagosome pathway [Homo sapiens]
(precedingEvent)	[Reaction:1236949] Translocation of antigenic peptides back to phagosomes via TAP [Homo sapiens]
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No pathways have been reviewed or authored by Proteasomal cleavage of partially digested antigen (immunoproteasome catalyst) (9912751)