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Details on Person CK2alpha phosphorylates BMAL1 (ARNTL) on serine-90

Class:Id	Reaction:9912401
_displayName	CK2alpha phosphorylates BMAL1 (ARNTL) on serine-90
_doRelease	TRUE
_timestamp	2025-02-18 21:00:50
authored	[InstanceEdit:9911591] May, Bruce, 2024-06-01
catalystActivity	[CatalystActivity:9920727] protein serine/threonine kinase activity of CSNK2A1 [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9912395] May, Bruce, 2024-06-08
edited	[InstanceEdit:9911591] May, Bruce, 2024-06-01
inferredFrom	[Reaction:9912393] CK2alpha phosphorylates Bmal1 (Arntl) on serine-97 [Mus musculus]
input	[EntityWithAccessionedSequence:400353] ARNTL [cytosol] [Homo sapiens] [SimpleEntity:29358] ATP [nucleoplasm]
internalReviewed	[InstanceEdit:9936833] Matthews, Lisa, 2025-01-27
isChimeric	FALSE
modified	[InstanceEdit:9920763] May, Bruce, 2024-09-03 [InstanceEdit:9923164] May, Bruce, 2024-09-30 [InstanceEdit:9928769] May, Bruce, 2024-11-17 [InstanceEdit:9936865] May, Bruce, 2025-01-27 [InstanceEdit:9938391] May, Bruce, 2025-02-14 [InstanceEdit:9938697] May, Bruce, 2025-02-18
name	CK2alpha phosphorylates BMAL1 (ARNTL) on serine-90
output	[EntityWithAccessionedSequence:9912391] p-S90-BMAL1 [cytosol] [Homo sapiens] [SimpleEntity:113582] ADP [nucleoplasm]
precedingEvent	[BlackBoxEvent:9911580] RORA,B,C positively regulates expression and NR1D1 (REV-ERBA) negatively regulates expression of BMAL1 (ARNTL) [Homo sapiens] [Reaction:9911560] RORA,B,C, EP300, PPARGC1A, NRIP1 bind BMAL1 (ARNTL) gene [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
regulatedBy	[NegativeRegulation:9923129] Negative regulation by 'CSNK2B [nucleoplasm]'
releaseDate	2025-03-26
reviewed	[InstanceEdit:9938389] Sancar, Aziz, 2025-02-14 [InstanceEdit:9938694] Albrecht, Urs, 2025-02-18
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9912408] R-HSA-9912401.1
structureModified	[InstanceEdit:9920763] May, Bruce, 2024-09-03 [InstanceEdit:9923164] May, Bruce, 2024-09-30
summation	[Summation:9928737] CK2alpha, the catalytic subunit of casein kinase II (CK2) ph...
(hasEvent)	[Pathway:9931529] Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK [Homo sapiens]
(precedingEvent)	[Reaction:9912390] p-S90-BMAL1 binds p-T451,T461-CLOCK [Homo sapiens]
(replacementInstances)	[_Deleted:9938750] Deletion of instance: 421320
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