Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person FepC:FepD:FepG transports ferrienterobactin from the periplasmic space to the cytosol

Class:IdReaction:9911603
_displayNameFepC:FepD:FepG transports ferrienterobactin from the periplasmic space to the cytosol
_doReleaseTRUE
_timestamp2025-05-21 07:41:13
authored[InstanceEdit:9638337] Stephan, Ralf, 2019-02-21
catalystActivity[CatalystActivity:9638318] ferric-enterobactin transmembrane transporter activity of FepDGC [plasma membrane]
compartment[Compartment:70101] cytosol
[Compartment:1222638] periplasmic space
[Compartment:876] plasma membrane
created[InstanceEdit:9911604] Stephan, Ralf, 2024-06-03
disease[Disease:3134792] bacterial infectious disease
edited[InstanceEdit:9948470] Stephan, Ralf, 2025-05-21
input[Complex:9638328] FeEnt:FepB [periplasmic space] [Escherichia coli]
[SimpleEntity:113592] ATP [cytosol]
internalReviewed[InstanceEdit:9915005] Gillespie, Marc E, 2024-07-02
[InstanceEdit:9917579] Gillespie, Marc E, 2024-08-08
isChimericFALSE
literatureReference[LiteratureReference:9638421] Docking of the periplasmic FecB binding protein to the FecCD transmembrane proteins in the ferric citrate transport system of Escherichia coli
[LiteratureReference:9638406] Identification of hydrophobic proteins FepD and FepG of the Escherichia coli ferrienterobactin permease
[LiteratureReference:9638377] Nucleotide sequence and genetic organization of the ferric enterobactin transport system: homology to other periplasmic binding protein-dependent systems in Escherichia coli
[LiteratureReference:9638388] Organization of genes encoding membrane proteins of the Escherichia coli ferrienterobactin permease
modified[InstanceEdit:9911640] Stephan, Ralf, 2024-06-03
[InstanceEdit:9911686] Stephan, Ralf, 2024-06-04
[InstanceEdit:9915006] Stephan, Ralf, 2024-07-02
[InstanceEdit:9915160] Stephan, Ralf, 2024-07-03
[InstanceEdit:9915824] D'Eustachio, Peter, 2024-07-16
[InstanceEdit:9917580] Stephan, Ralf, 2024-08-08
[InstanceEdit:9931098] Stephan, Ralf, 2024-12-10
[InstanceEdit:9933047] Stephan, Ralf, 2024-12-23
[InstanceEdit:9948469] Stephan, Ralf, 2025-05-21
nameFepC:FepD:FepG transports ferrienterobactin from the periplasmic space to the cytosol
output[SimpleEntity:9638381] FeEnt [cytosol]
[EntityWithAccessionedSequence:9638312] FepB [periplasmic space] [Escherichia coli]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29372] Pi [cytosol]
precedingEvent
relatedSpecies[Species:159879] Escherichia coli
releaseDate2025-06-18
reviewStatus[ReviewStatus:9821383] three stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9911609] R-HSA-9911603.1
structureModified[InstanceEdit:9911686] Stephan, Ralf, 2024-06-04
summation[Summation:9638380] The ferrienterobactin transporter complex composed of ferric...
(hasEvent)[Pathway:9638334] Iron assimilation using enterobactin [Homo sapiens]
(precedingEvent)[Reaction:9911599] Fes hydrolyses ferrienterobactin to DHBS [Homo sapiens]
[Reaction:9927945] YqjH reduces FeEnt [Homo sapiens]
[NegativePrecedingEvent:9939562] Futile Cycle: FepC:FepD:FepG transports ferrienterobactin from the periplasmic space to the cytosol
(replacementInstances)[_Deleted:9911637] Deletion of instance: 9638401
[Change default viewing format]
No pathways have been reviewed or authored by FepC:FepD:FepG transports ferrienterobactin from the periplasmic space to the cytosol (9911603)