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Details on Person RORA,B,C positively regulates expression and NR1D1 (REV-ERBA) negatively regulates expression of BMAL1 (ARNTL)

Class:Id	BlackBoxEvent:9911580
_displayName	RORA,B,C positively regulates expression and NR1D1 (REV-ERBA) negatively regulates expression of BMAL1 (ARNTL)
_doRelease	TRUE
_timestamp	2025-02-18 21:10:29
authored	[InstanceEdit:9911300] May, Bruce, 2024-05-28
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:9911579] May, Bruce, 2024-06-01
edited	[InstanceEdit:9911300] May, Bruce, 2024-05-28
inferredFrom	[BlackBoxEvent:9911570] Rora,b,c positivley regulates and Nr1d1 (Rev-erba) negatively regulates expression of Bmal1 (Arntl) [Mus musculus]
input	[EntityWithAccessionedSequence:5640173] ARNTL gene [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9936833] Matthews, Lisa, 2025-01-27
literatureReference	[LiteratureReference:5669307] Modulation of clock gene expression by the transcriptional coregulator receptor interacting protein 140 (RIP140)
modified	[InstanceEdit:9931548] May, Bruce, 2024-12-12 [InstanceEdit:9935064] May, Bruce, 2025-01-12 [InstanceEdit:9936865] May, Bruce, 2025-01-27 [InstanceEdit:9938391] May, Bruce, 2025-02-14 [InstanceEdit:9938697] May, Bruce, 2025-02-18
name	RORA,B,C positively regulates expression and NR1D1 (REV-ERBA) negatively regulates expression of BMAL1 (ARNTL) ARNTL gene produces ARNTL
output	[EntityWithAccessionedSequence:400353] ARNTL [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9911560] RORA,B,C, EP300, PPARGC1A, NRIP1 bind BMAL1 (ARNTL) gene [Homo sapiens] [BlackBoxEvent:1368140] Expression of PPARGC1A (PGC-1alpha) [Homo sapiens] [BlackBoxEvent:9922984] Phosphorylated BMAL1:CLOCK positively regulates expression of RORA [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
regulatedBy	[NegativeGeneExpressionRegulation:421342] Negative gene expression regulation by 'NR1D1:heme:Corepressors:ARNTL gene [nucleoplasm]' [PositiveGeneExpressionRegulation:5656526] Positive gene expression regulation by 'SIRT1 [nucleoplasm]' [PositiveGeneExpressionRegulation:9911571] Positive gene expression regulation by 'RORA,B,C:Coactivator:BMAL1 gene [nucleoplasm]'
releaseDate	2025-03-26
reviewed	[InstanceEdit:9938389] Sancar, Aziz, 2025-02-14 [InstanceEdit:9938694] Albrecht, Urs, 2025-02-18
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9911590] R-HSA-9911580.1
summation	[Summation:9911566] RORA, RORB, or RORC bind ROR responsive elements (RREs, RORE...
(hasEvent)	[Pathway:9931509] Expression of BMAL (ARNTL), CLOCK, and NPAS2 [Homo sapiens]
(precedingEvent)	[Reaction:9912401] CK2alpha phosphorylates BMAL1 (ARNTL) on serine-90 [Homo sapiens]
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No pathways have been reviewed or authored by RORA,B,C positively regulates expression and NR1D1 (REV-ERBA) negatively regulates expression of BMAL1 (ARNTL) (9911580)