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Query author contributions in Reactome

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Details on Person Diagram of Action of antimicrobials and antimicrobial resistance

Class:IdPathwayDiagram:9911551
_displayNameDiagram of Action of antimicrobials and antimicrobial resistance
_timestamp2026-03-07 01:38:30
created[InstanceEdit:9911544] Stephan, Ralf, 2024-06-01
height1717
modified[InstanceEdit:9911592] Stephan, Ralf, 2024-06-02
[InstanceEdit:9912295] Stephan, Ralf, 2024-06-07
[InstanceEdit:9912581] Stephan, Ralf, 2024-06-09
[InstanceEdit:9913090] Stephan, Ralf, 2024-06-11
[InstanceEdit:9913123] Stephan, Ralf, 2024-06-11
[InstanceEdit:9913145] Stephan, Ralf, 2024-06-12
[InstanceEdit:9913378] Stephan, Ralf, 2024-06-13
[InstanceEdit:9913448] Stephan, Ralf, 2024-06-14
[InstanceEdit:9913677] Stephan, Ralf, 2024-06-17
[InstanceEdit:9913835] Stephan, Ralf, 2024-06-18
[InstanceEdit:9913916] Stephan, Ralf, 2024-06-19
[InstanceEdit:9913947] Stephan, Ralf, 2024-06-19
[InstanceEdit:9914076] Stephan, Ralf, 2024-06-20
[InstanceEdit:9914244] Stephan, Ralf, 2024-06-22
[InstanceEdit:9931098] Stephan, Ralf, 2024-12-10
[InstanceEdit:9931162] Stephan, Ralf, 2024-12-11
[InstanceEdit:9931555] Stephan, Ralf, 2024-12-12
[InstanceEdit:9931776] Stephan, Ralf, 2024-12-13
[InstanceEdit:9931960] Stephan, Ralf, 2024-12-14
[InstanceEdit:9953209] Stephan, Ralf, 2025-05-29
[InstanceEdit:9953272] Matthews, Lisa, 2025-06-01
[InstanceEdit:9953524] Matthews, Lisa, 2025-06-03
[InstanceEdit:9964254] Stephan, Ralf, 2025-08-21
[InstanceEdit:9964560] Matthews, Lisa, 2025-08-25
[InstanceEdit:9964561] Matthews, Lisa, 2025-08-25
[InstanceEdit:9971557] Stephan, Ralf, 2025-11-07
[InstanceEdit:9971764] Matthews, Lisa, 2025-11-11
[InstanceEdit:9984369] Matthews, Lisa, 2026-03-07
representedPathway[Pathway:9638737] Action of antimicrobials and antimicrobial resistance [Homo sapiens]
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id="273" points="1375 1192" /> </Inputs> <Outputs> <Output id="274" /> </Outputs> <Catalysts> <Catalyst id="275" points="1367 1268" /> </Catalysts> <Properties> <displayName>TEM-1 hydrolyzes penicillin G</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="276" reactomeId="9911518" points="1215 1238, 1216 1267, 1252 1315" position="1216 1267" lineWidth="1.0"> <Inputs> <Input id="272" points="1257 1186" /> <Input id="281" points="1158 1221" /> </Inputs> <Outputs> <Output id="274" /> </Outputs> <Catalysts> <Catalyst id="278" points="1165 1268" /> </Catalysts> <Properties> <displayName>OXA-9 hydrolyzes penicillin G</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="279" reactomeId="9911513" points="1063 1229, 1064 1269, 1065 1316" position="1064 1269" lineWidth="1.0"> <Inputs> <Input id="280" points="1046 1184" /> <Input id="281" points="1112 1219" /> </Inputs> <Outputs> <Output id="285" /> </Outputs> <Catalysts> <Catalyst id="282" points="1003 1269" /> </Catalysts> <Properties> <displayName>BlaSHV-12 hydrolyzes ceftriaxone</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="286" reactomeId="9911519" points="882 1229, 882 1271, 849 1316" position="882 1271" lineWidth="1.0"> <Inputs> <Input id="287" points="847 1182" /> <Input id="288" points="925 1186" /> </Inputs> <Outputs> <Output id="290" /> </Outputs> <Catalysts> <Catalyst id="282" points="926 1270" /> </Catalysts> <Properties> <displayName>BlaSHV-12 hydrolyzes cephalothin</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="291" reactomeId="9911515" points="794 1233, 794 1266, 820 1316" position="794 1266" lineWidth="1.0"> <Inputs> <Input id="287" points="827 1182" /> <Input id="292" points="754 1189" /> </Inputs> <Outputs> <Output id="290" /> </Outputs> <Catalysts> <Catalyst id="293" points="743 1266" /> </Catalysts> <Properties> <displayName>KPC-2 hydrolyzes cephalothin</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="294" reactomeId="9911509" points="391 901, 391 926, 391 953" position="391 926" lineWidth="1.0"> <Inputs> <Input id="295" points="326 872" /> <Input id="296" points="391 845" /> </Inputs> <Outputs> <Output id="297" points="365 1045" /> <Output id="298" points="320 975" /> </Outputs> <Catalysts> <Catalyst id="487" points="343 925" /> </Catalysts> <Properties> <displayName>RMTases methylate 16S ribosomal RNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="302" reactomeId="9911511" points="2029 833, 2030 834, 2006 854" position="2030 834" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="303" points="2056 823" /> <Input id="304" points="1996 819" /> </Inputs> <Outputs> <Output id="305" /> </Outputs> <Properties> <displayName>Qnr binds gyrase</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="306" reactomeId="9911514" points="460 630, 460 628, 459 630" position="460 628" lineWidth="1.0"> <Inputs> <Input id="308" points="461 652" /> <Input id="334" points="362 660" /> <Input id="335" points="346 694" /> </Inputs> <Outputs> <Output id="309" points="458 547" /> <Output id="310" points="560 701" /> <Output id="311" points="534 661" /> </Outputs> <Catalysts> <Catalyst id="312" points="390 569" /> </Catalysts> <Properties> <displayName>MacA:MacB:TolC transports azithromycin from the cytosol to the periplasm</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="313" reactomeId="9911510" points="457 510, 457 418, 459 303" position="457 418" lineWidth="1.0"> <Inputs> <Input id="309" /> </Inputs> <Outputs> <Output id="314" /> </Outputs> <Catalysts> <Catalyst id="312" points="390 473" /> </Catalysts> <Properties> <displayName>MacA:MacB:TolC transports azithromycin from the periplasm to the extracellular region</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="315" reactomeId="9911512" points="775 630, 776 629, 775 631" position="776 629" lineWidth="1.0"> <Inputs> <Input id="316" points="841 603" /> <Input id="515" points="777 669" /> </Inputs> <Outputs> <Output id="518" points="775 554" /> <Output id="317" points="842 657" /> </Outputs> <Catalysts> <Catalyst id="318" points="713 572" /> </Catalysts> <Properties> <displayName>AcrA:AcrB:TolC transports antibiotics from the cytosol to the periplasm</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="321" reactomeId="9911516" points="775 501, 776 416, 780 323" position="776 416" lineWidth="1.0"> <Inputs> <Input id="518" /> </Inputs> <Outputs> <Output id="525" /> </Outputs> <Catalysts> <Catalyst id="318" points="713 472" /> </Catalysts> <Properties> <displayName>AcrA:AcrB:TolC transports antibiotics from the periplasm to the extracellular region</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="322" reactomeId="9911517" points="1266 628, 1269 628, 1273 630" position="1269 628" lineWidth="1.0"> <Inputs> <Input id="354" points="1415 740" /> <Input id="358" points="1417 588" /> </Inputs> <Outputs> <Output id="355" points="1428 556" /> <Output id="360" points="1385 674" /> </Outputs> <Catalysts> <Catalyst id="325" points="1218 628" /> </Catalysts> <Properties> <displayName>MdfA transports tetracyclines from the cytosol to the periplasmic space</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="353" reactomeId="9913106" points="1491 629, 1489 629, 1491 629" position="1489 629" lineWidth="1.0"> <Inputs> <Input id="354" points="1444 740" /> <Input id="358" points="1454 596" /> </Inputs> <Outputs> <Output id="355" points="1468 556" /> <Output id="360" points="1422 671" /> </Outputs> <Catalysts> <Catalyst id="356" points="1527 629" /> </Catalysts> <Properties> <displayName>TetB exports tetracyclines</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="372" reactomeId="9913128" points="1465 629, 1465 629, 1465 629" position="1465 629" lineWidth="1.0"> <Inputs> <Input id="354" points="1441 740" /> <Input id="358" points="1445 603" /> </Inputs> <Outputs> <Output id="355" points="1463 556" /> <Output id="360" points="1422 667" /> </Outputs> <Catalysts> <Catalyst id="373" points="1428 629" /> </Catalysts> <Properties> <displayName>TetA exports tetracyclines</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="374" reactomeId="9911463" points="475 1246, 438 1245, 395 1246" position="438 1245" lineWidth="1.0" reactionType="Transition"> <Inputs> <Input id="375" points="530 1231" /> <Input id="376" points="539 1265" /> </Inputs> <Outputs> <Output id="377" points="317 1244" /> <Output id="378" points="305 1197" /> <Output id="382" points="307 1297" /> </Outputs> <Catalysts> <Catalyst id="379" points="401 1155" /> </Catalysts> <Inhibitors> <Inhibitor id="380" points="491 1190" /> </Inhibitors> <Properties> <displayName>MrcB elongates peptidoglycan</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="383" reactomeId="9911461" points="544 1094, 545 1095, 520 1143" position="545 1095" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="379" points="413 1118, 459 1079" /> <Input id="577" points="945 808" /> </Inputs> <Outputs> <Output id="380" /> </Outputs> <Properties> <displayName>β-lactam antibiotics bind MrcB</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="388" reactomeId="9911462" points="492 885, 495 882, 574 942" position="495 882" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="389" points="540 841" /> <Input id="296" points="434 845" /> </Inputs> <Outputs> <Output id="390" /> </Outputs> <Inhibitors> <Inhibitor id="297" points="377 1045" /> </Inhibitors> <Properties> <displayName>Aminoglycoside antibiotics bind Kpn 16S rRNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="391" reactomeId="9912784" points="1438 825, 1438 825, 1400 834" position="1438 825" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="354" points="1438 780" /> <Input id="392" points="1457 830" /> </Inputs> <Outputs> <Output id="393" /> </Outputs> <Properties> <displayName>Tetracycline antibiotics bind to 16S rRNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="394" reactomeId="9913142" points="1901 847, 1905 866, 1925 964" position="1905 866" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="395" points="1888 777" /> <Input id="304" points="1945 825" /> </Inputs> <Outputs> <Output id="396" /> </Outputs> <Inhibitors> <Inhibitor id="305" points="1955 874" /> <Inhibitor id="444" points="1795 956" /> </Inhibitors> <Properties> <displayName>Fluoroquinolones bind gyrase</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="440" reactomeId="9913373" points="1732 866, 1732 888, 1733 913" position="1732 888" lineWidth="1.0"> <Inputs> <Input id="441" points="1685 851" /> <Input id="442" points="1732 826" /> </Inputs> <Outputs> <Output id="443" points="1684 942" /> <Output id="444" points="1760 956" /> <Output id="447" points="1682 997" /> </Outputs> <Catalysts> <Catalyst id="445" points="1771 887" /> </Catalysts> <Properties> <displayName>AAC(6′)-Ib acetylates ciprofloxacin</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="448" points="1771 789, 1838 765" position="1804 777" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="442" /> </Inputs> <Outputs> <Output id="395" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="461" reactomeId="9913437" points="1827 626, 1826 626, 1827 624" position="1826 626" lineWidth="1.0"> <Inputs> <Input id="395" points="1876 728" /> <Input id="467" points="1851 606" /> </Inputs> <Outputs> <Output id="462" points="1826 575" /> <Output id="465" points="1800 651" /> </Outputs> <Catalysts> <Catalyst id="463" points="1764 626" /> </Catalysts> <Properties> <displayName>Pef exports fluoroquinolones</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="468" reactomeId="9913672" points="1847 631, 1845 631, 1847 631" position="1845 631" lineWidth="1.0"> <Inputs> <Input id="395" points="1879 728" /> <Input id="467" points="1859 614" /> </Inputs> <Outputs> <Output id="462" points="1830 575" /> <Output id="465" points="1800 657" /> </Outputs> <Catalysts> <Catalyst id="469" points="1894 629" /> </Catalysts> <Properties> <displayName>OqxA exports fluoroquinolones</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="516" points="1838 756, 1253 825, 820 701" position="1253 825" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="395" /> </Inputs> <Outputs> <Output id="515" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="517" points="594 791, 747 714" position="670 752" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="389" /> </Inputs> <Outputs> <Output id="515" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="519" points="1785 526, 1433 372, 1298 373, 817 516" position="1365 372" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="462" /> </Inputs> <Outputs> <Output id="518" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndEntitySetLink id="520" points="775 554, 777 669" position="776 611" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="518" /> </Inputs> <Outputs> <Output id="515" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndMemberLink id="522" points="476 689, 529 744, 736 698" position="529 744" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="308" /> </Inputs> <Outputs> <Output id="515" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="523" points="505 527, 733 527" position="619 527" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="309" /> </Inputs> <Outputs> <Output id="518" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="531" points="1379 771, 1252 798, 820 699" position="1252 798" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="354" /> </Inputs> <Outputs> <Output id="515" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="532" points="1430 515, 1173 380, 939 384, 798 501" position="1056 382" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="355" /> </Inputs> <Outputs> <Output id="518" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="572" reactomeId="9914089" points="973 631, 973 631, 973 631" position="973 631" lineWidth="1.0"> <Inputs> <Input id="316" points="878 602" /> <Input id="577" points="973 754" /> </Inputs> <Outputs> <Output id="317" points="879 659" /> <Output id="573" points="973 556" /> </Outputs> <Catalysts> <Catalyst id="575" points="1046 569" /> </Catalysts> <Properties> <displayName>MdtE:MdtF:TolC exports beta-lactams to the periplasm</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="574" points="932 529, 817 527" position="874 528" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="573" /> </Inputs> <Outputs> <Output id="518" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="581" reactomeId="9914083" points="972 505, 972 420, 975 326" position="972 420" lineWidth="1.0"> <Inputs> <Input id="573" /> </Inputs> <Outputs> <Output id="582" /> </Outputs> <Catalysts> <Catalyst id="575" points="1046 482" /> </Catalysts> <Properties> <displayName>MdtE:MdtF:TolC exports beta-lactams to extracellular space</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="598" points="842 1145, 966 808" position="904 976" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="287" /> </Inputs> <Outputs> <Output id="577" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="599" points="1038 1147, 977 808" position="1007 977" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="280" /> </Inputs> <Outputs> <Output id="577" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="600" points="1257 1146, 990 808" position="1123 977" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="272" /> </Inputs> <Outputs> <Output id="577" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="633" reactomeId="9931163" points="2115 627, 2115 627, 2115 627" position="2115 627" lineWidth="1.0"> <Inputs> <Input id="634" points="2095 697" /> <Input id="638" stoichiometry="2" points="2146 603" /> </Inputs> <Outputs> <Output id="635" points="2095 555" /> <Output id="640" stoichiometry="2" points="2151 656" /> </Outputs> <Catalysts> <Catalyst id="636" points="2070 627" /> </Catalysts> <Properties> <displayName>Gdx dimer exports cationic aromatics to periplasm</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="679" reactomeId="9931565" points="2225 629, 2224 631, 2222 632" position="2224 631" lineWidth="1.0"> <Inputs> <Input id="680" points="2257 699" /> <Input id="638" stoichiometry="2" points="2183 601" /> </Inputs> <Outputs> <Output id="683" points="2265 552" /> <Output id="640" stoichiometry="2" points="2188 657" /> </Outputs> <Catalysts> <Catalyst id="686" points="2271 630" /> </Catalysts> <Properties> <displayName>EmrE dimer exports xenobiotics to periplasm</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process>
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No pathways have been reviewed or authored by Diagram of Action of antimicrobials and antimicrobial resistance (9911551)
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