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Details on Person MdfA transports tetracyclines from the cytosol to the periplasmic space

Class:Id	Reaction:9911517
_displayName	MdfA transports tetracyclines from the cytosol to the periplasmic space
_doRelease	TRUE
_timestamp	2025-05-21 07:44:44
authored	[InstanceEdit:9637715] Stephan, Ralf, 2019-02-19
catalystActivity	[CatalystActivity:9639470] xenobiotic transmembrane transporter activity of MdfA [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:1222638] periplasmic space
created	[InstanceEdit:9911521] Stephan, Ralf, 2024-06-01
disease	[Disease:3134792] bacterial infectious disease
edited	[InstanceEdit:9948470] Stephan, Ralf, 2025-05-21
input	[SimpleEntity:8858135] H+ [periplasmic space] [Complex:9913101] tetracyclines:Mg2+ [cytosol]
internalReviewed	[InstanceEdit:9915005] Gillespie, Marc E, 2024-07-02 [InstanceEdit:9917579] Gillespie, Marc E, 2024-08-08
isChimeric	FALSE
literatureReference	[LiteratureReference:9639433] MdfA, an Escherichia coli multidrug resistance protein with an extraordinarily broad spectrum of drug recognition [LiteratureReference:9639463] The Escherichia coli multidrug transporter MdfA catalyzes both electrogenic and electroneutral transport reactions [LiteratureReference:9911346] The multidrug-resistance transporter MdfA from Escherichia coli: crystallization and X-ray diffraction analysis
modified	[InstanceEdit:9911544] Stephan, Ralf, 2024-06-01 [InstanceEdit:9912581] Stephan, Ralf, 2024-06-09 [InstanceEdit:9913947] Stephan, Ralf, 2024-06-19 [InstanceEdit:9913951] Stephan, Ralf, 2024-06-19 [InstanceEdit:9915006] Stephan, Ralf, 2024-07-02 [InstanceEdit:9915160] Stephan, Ralf, 2024-07-03 [InstanceEdit:9917580] Stephan, Ralf, 2024-08-08 [InstanceEdit:9931098] Stephan, Ralf, 2024-12-10 [InstanceEdit:9933047] Stephan, Ralf, 2024-12-23 [InstanceEdit:9948469] Stephan, Ralf, 2025-05-21
name	MdfA transports tetracyclines from the cytosol to the periplasmic space
output	[SimpleEntity:70106] H+ [cytosol] [Complex:9913110] tetracyclines:Mg2+ [periplasmic space]
relatedSpecies	[Species:159879] Escherichia coli
releaseDate	2025-06-18
reviewStatus	[ReviewStatus:9821383] three stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9911527] R-HSA-9911517.1
structureModified	[InstanceEdit:9912581] Stephan, Ralf, 2024-06-09 [InstanceEdit:9913947] Stephan, Ralf, 2024-06-19
summation	[Summation:9639452] Major facilitator-type (MFS) efflux pumps consist of a singl...
(hasEvent)	[Pathway:9913143] Antimicrobial resistance [Homo sapiens]
(precedingEvent)	[Reaction:9911516] AcrA:AcrB:TolC transports antibiotics from the periplasm to the extracellular region [Homo sapiens]
(replacementInstances)	[_Deleted:9911553] Deletion of instance: 9639493
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