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Details on Person AcrA:AcrB:TolC transports antibiotics from the cytosol to the periplasm

Class:Id	Reaction:9911512
_displayName	AcrA:AcrB:TolC transports antibiotics from the cytosol to the periplasm
_doRelease	TRUE
_timestamp	2025-05-21 07:36:48
authored	[InstanceEdit:9638337] Stephan, Ralf, 2019-02-21
catalystActivity	[CatalystActivity:9639457] xenobiotic transmembrane transporter activity of AcrA:AcrB:TolC [cell outer membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:1222638] periplasmic space [Compartment:20798] cell outer membrane
created	[InstanceEdit:9911521] Stephan, Ralf, 2024-06-01
disease	[Disease:3134792] bacterial infectious disease
edited	[InstanceEdit:9948470] Stephan, Ralf, 2025-05-21
input	[SimpleEntity:8858135] H+ [periplasmic space] [DefinedSet:9913929] AcrAB:TolC cargo [cytosol]
internalReviewed	[InstanceEdit:9917579] Gillespie, Marc E, 2024-08-08
isChimeric	FALSE
literatureReference	[LiteratureReference:9639485] Site-directed mutagenesis reveals amino acid residues in the Escherichia coli RND efflux pump AcrB that confer macrolide resistance [LiteratureReference:9639435] AcrA is a highly asymmetric protein capable of spanning the periplasm [LiteratureReference:9911303] RND transporters in the living world [LiteratureReference:9911195] Structure, Assembly, and Function of Tripartite Efflux and Type 1 Secretion Systems in Gram-Negative Bacteria [LiteratureReference:9931779] Entry into and release of solvents by Escherichia coli in an organic-aqueous two-liquid-phase system and substrate specificity of the AcrAB-TolC solvent-extruding pump
modified	[InstanceEdit:9911544] Stephan, Ralf, 2024-06-01 [InstanceEdit:9911592] Stephan, Ralf, 2024-06-02 [InstanceEdit:9913916] Stephan, Ralf, 2024-06-19 [InstanceEdit:9914076] Stephan, Ralf, 2024-06-20 [InstanceEdit:9914259] Stephan, Ralf, 2024-06-23 [InstanceEdit:9915006] Stephan, Ralf, 2024-07-02 [InstanceEdit:9915160] Stephan, Ralf, 2024-07-03 [InstanceEdit:9917580] Stephan, Ralf, 2024-08-08 [InstanceEdit:9931098] Stephan, Ralf, 2024-12-10 [InstanceEdit:9931776] Stephan, Ralf, 2024-12-13 [InstanceEdit:9933047] Stephan, Ralf, 2024-12-23 [InstanceEdit:9948469] Stephan, Ralf, 2025-05-21
name	AcrA:AcrB:TolC transports antibiotics from the cytosol to the periplasm
output	[SimpleEntity:70106] H+ [cytosol] [DefinedSet:9913925] AcrAB:TolC cargo [periplasmic space]
relatedSpecies	[Species:159879] Escherichia coli
releaseDate	2025-06-18
reviewStatus	[ReviewStatus:9821383] three stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9911526] R-HSA-9911512.1
structureModified	[InstanceEdit:9911592] Stephan, Ralf, 2024-06-02 [InstanceEdit:9913916] Stephan, Ralf, 2024-06-19
summation	[Summation:9639497] The tripartite efflux system acrA:acrB:tolC is the predomina...
(hasEvent)	[Pathway:9913143] Antimicrobial resistance [Homo sapiens]
(precedingEvent)	[Reaction:9911516] AcrA:AcrB:TolC transports antibiotics from the periplasm to the extracellular region [Homo sapiens] [Reaction:9914083] MdtE:MdtF:TolC exports beta-lactams to extracellular space [Homo sapiens]
(replacementInstances)	[_Deleted:9911548] Deletion of instance: 9639434
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No pathways have been reviewed or authored by AcrA:AcrB:TolC transports antibiotics from the cytosol to the periplasm (9911512)