Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person MacA:MacB:TolC transports azithromycin from the periplasm to the extracellular region

Class:Id	Reaction:9911510
_displayName	MacA:MacB:TolC transports azithromycin from the periplasm to the extracellular region
_doRelease	TRUE
_timestamp	2025-05-21 07:44:34
authored	[InstanceEdit:9911196] Stephan, Ralf, 2024-05-27
catalystActivity	[CatalystActivity:9639450] porin activity of MacA:MacB:TolC [cell outer membrane]
compartment	[Compartment:1222638] periplasmic space [Compartment:20798] cell outer membrane [Compartment:984] extracellular region
created	[InstanceEdit:9911521] Stephan, Ralf, 2024-06-01
disease	[Disease:3134792] bacterial infectious disease
edited	[InstanceEdit:9948470] Stephan, Ralf, 2025-05-21
input	[ChemicalDrug:9911188] azithromycin [periplasmic space]
internalReviewed	[InstanceEdit:9915005] Gillespie, Marc E, 2024-07-02 [InstanceEdit:9917579] Gillespie, Marc E, 2024-08-08
isChimeric	FALSE
literatureReference	[LiteratureReference:9639429] Novel macrolide-specific ABC-type efflux transporter in Escherichia coli [LiteratureReference:9911186] Structures of sequential open states in a symmetrical opening transition of the TolC exit duct [LiteratureReference:9911195] Structure, Assembly, and Function of Tripartite Efflux and Type 1 Secretion Systems in Gram-Negative Bacteria
modified	[InstanceEdit:9911544] Stephan, Ralf, 2024-06-01 [InstanceEdit:9915006] Stephan, Ralf, 2024-07-02 [InstanceEdit:9915160] Stephan, Ralf, 2024-07-03 [InstanceEdit:9917580] Stephan, Ralf, 2024-08-08 [InstanceEdit:9931098] Stephan, Ralf, 2024-12-10 [InstanceEdit:9933047] Stephan, Ralf, 2024-12-23 [InstanceEdit:9948469] Stephan, Ralf, 2025-05-21
name	MacA:MacB:TolC transports azithromycin from the periplasm to the extracellular region
output	[ChemicalDrug:9639439] azithromycin [extracellular region]
precedingEvent	[Reaction:9911514] MacA:MacB:TolC transports azithromycin from the cytosol to the periplasm [Homo sapiens]
relatedSpecies	[Species:159879] Escherichia coli
releaseDate	2025-06-18
reviewStatus	[ReviewStatus:9821383] three stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9911530] R-HSA-9911510.1
summation	[Summation:9911200] The tripartite efflux system MacA:MacB:TolC in enterobacteri...
(hasEvent)	[Pathway:9913143] Antimicrobial resistance [Homo sapiens]
(replacementInstances)	[_Deleted:9911537] Deletion of instance: 9911199
[Change default viewing format]

No pathways have been reviewed or authored by MacA:MacB:TolC transports azithromycin from the periplasm to the extracellular region (9911510)