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Details on Person
ELANE (also known as ELA2 or NE), a human neutrophil elas...
| Class:Id | Summation:9911492 |
|---|---|
| _displayName | ELANE (also known as ELA2 or NE), a human neutrophil elas... |
| _timestamp | 2024-06-04 18:54:07 |
| created | [InstanceEdit:9911494] Orlic-Milacic, Marija, 2024-05-31 |
| literatureReference | [LiteratureReference:9911328] A novel notch protein, N2N, targeted by neutrophil elastase and implicated in hereditary neutropenia |
| modified | [InstanceEdit:9911695] Orlic-Milacic, Marija, 2024-06-04 |
| text | ELANE (also known as ELA2 or NE), a human neutrophil elastase, is a serine protease that interacts with NOTCH2NLA (also known as N2N or NOTCH2NL) and cleaves it within EGF repeats (Duan et al. 2004). ELANE-mediated proteolysis of NOTCH2NLA is slowed down by the C-terminus of NOTCH2NLA (Duan et al. 2004). Some of the ELANE mutations that cause cyclic and severe congenital neutropenia disrupt the interaction between NOTCH2NLA and ELANE and impair ELANE-mediated NOTCH2NLA proteolysis (Duan et al. 2004). NOTCH2 may also be cleaved by ELANE (Duan et al. 2004). Wild type ELANE inhibits NOTCH2 transcriptional activity in a dose-dependent manner (Duan et al. 2004). |
| (summation) | [BlackBoxEvent:9911236] ELANE cleaves NOTCH2NLA [Homo sapiens] |
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ELANE (also known as ELA2 or NE), a human neutrophil elas... (9911492)
