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Details on Person Aminoglycoside antibiotics bind Kpn 16S rRNA

Class:Id	Reaction:9911462
_displayName	Aminoglycoside antibiotics bind Kpn 16S rRNA
_doRelease	TRUE
_timestamp	2025-05-21 07:37:33
authored	[InstanceEdit:9638888] Stephan, Ralf, 2019-03-06
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9911464] Stephan, Ralf, 2024-05-31
disease	[Disease:3134792] bacterial infectious disease
edited	[InstanceEdit:9948470] Stephan, Ralf, 2025-05-21
input	[EntityWithAccessionedSequence:9638945] Kpn 16S rRNA [cytosol] [Klebsiella pneumoniae] [DefinedSet:9912569] Aminoglycoside antibiotics [cytosol]
internalReviewed	[InstanceEdit:9915005] Gillespie, Marc E, 2024-07-02 [InstanceEdit:9917579] Gillespie, Marc E, 2024-08-08
isChimeric	FALSE
literatureReference	[LiteratureReference:9638916] Ribosome-targeting antibiotics and mechanisms of bacterial resistance [LiteratureReference:9638920] Crystal structures of complexes between aminoglycosides and decoding A site oligonucleotides: role of the number of rings and positive charges in the specific binding leading to miscoding [LiteratureReference:9638919] Misreading of RNA codewords induced by aminoglycoside antibiotics
modified	[InstanceEdit:9911469] Stephan, Ralf, 2024-05-31 [InstanceEdit:9912551] Stephan, Ralf, 2024-06-09 [InstanceEdit:9912790] Stephan, Ralf, 2024-06-10 [InstanceEdit:9915006] Stephan, Ralf, 2024-07-02 [InstanceEdit:9917580] Stephan, Ralf, 2024-08-08 [InstanceEdit:9931098] Stephan, Ralf, 2024-12-10 [InstanceEdit:9933047] Stephan, Ralf, 2024-12-23 [InstanceEdit:9948469] Stephan, Ralf, 2025-05-21
name	Aminoglycoside antibiotics bind Kpn 16S rRNA
output	[Complex:9638951] 16S rRNA:aminoglycoside antibiotics [cytosol] [Klebsiella pneumoniae]
regulatedBy	[NegativeRegulation:9911465] Negative regulation by '7mG-16S rRNA (Kpn) [cytosol]'
relatedSpecies	[Species:9638647] Klebsiella pneumoniae
releaseDate	2025-06-18
reviewStatus	[ReviewStatus:9821383] three stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9911468] R-HSA-9911462.1
structureModified	[InstanceEdit:9912551] Stephan, Ralf, 2024-06-09
summation	[Summation:9638927] Gentamicin is an aminoglycoside antimicrobial. Aminoglycosid...
(hasEvent)	[Pathway:9638771] Action of antimicrobials [Homo sapiens]
(replacementInstances)	[_Deleted:9911473] Deletion of instance: 9638759 [_Deleted:9911474] Deletion of instance: 9638915
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No pathways have been reviewed or authored by Aminoglycoside antibiotics bind Kpn 16S rRNA (9911462)