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Details on Person UniProt:Q15008 PSMD6

Class:Id	ReferenceGeneProduct:99114
_chainChangeLog	chain:1-389 added on Fri February 6 2015;chain:1-389 removed on Tue November 3 2015;initiator methionine:1 added on Tue November 3 2015;chain:2-389 added on Tue November 3 2015;initiator methionine:1 for 99114 removed on Fri Nov 03 2023;initiator methionine: for 99114 added on Fri Nov 03 2023;initiator methionine: for 99114 removed on Fri Aug 15 2025;initiator methionine:1 for 99114 added on Fri Aug 15 2025
_displayName	UniProt:Q15008 PSMD6
_timestamp	2025-08-15 21:48:09
chain	initiator methionine:1 chain:2-389
checksum	8843E6684AE91ACD
comment	FUNCTION Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.SUBUNIT Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD6, a base containing 6 ATPases and few additional components.INTERACTION Belongs to the proteasome subunit S10 family.
description	recommendedName: 26S proteasome non-ATPase regulatory subunit 6 alternativeName: 26S proteasome regulatory subunit RPN7 alternativeName: 26S proteasome regulatory subunit S10 alternativeName: Breast cancer-associated protein SGA-113M alternativeName: Phosphonoformate immuno-associated protein 4 alternativeName: Proteasome regulatory particle subunit p44S10 alternativeName: p42A
geneName	PSMD6 KIAA0107 PFAAP4
identifier	Q15008
isSequenceChanged	FALSE
keyword	3D-structure Alternative splicing Proteasome Proteomics identification Reference proteome
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
name	PSMD6
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:9003170] ENSEMBL:ENSG00000163636 PSMD6 [Homo sapiens]
secondaryIdentifier	PSMD6_HUMAN A8K2E0 E9PHI9 Q6UV22
sequenceLength	389
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:8971637] UniProt:Q15008-1 PSMD6 [Homo sapiens] [ReferenceIsoform:8971638] UniProt:Q15008-2 PSMD6 [Homo sapiens] [ReferenceIsoform:8971639] UniProt:Q15008-3 PSMD6 [Homo sapiens] [ReferenceIsoform:8971640] UniProt:Q15008-4 PSMD6 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:68804] PSMD6 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:174316] PSMD6 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:6800440] PSMD6 [ficolin-1-rich granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:6800454] PSMD6 [extracellular exosome] [Homo sapiens] [EntityWithAccessionedSequence:6801036] PSMD6 [secretory granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:6806486] PSMD6 [extracellular region] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:Q15008 PSMD6 (99114)