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Details on Person CPT1B transfers PALM to CAR

Class:Id	Reaction:9911362
_displayName	CPT1B transfers PALM to CAR
_doRelease	TRUE
_timestamp	2024-08-20 17:45:00
authored	[InstanceEdit:9911357] D'Eustachio, Peter, 2024-05-29
catalystActivity	[CatalystActivity:9911359] carnitine O-palmitoyltransferase activity of CPT1B [mitochondrial outer membrane]
catalystActivityReference	[CatalystActivityReference:9911370] carnitine O-palmitoyltransferase activity of CPT1B [mitochondrial outer membrane] Functional studies of yeast-expressed human heart muscle carnitine palmitoyltransferase I
compartment	[Compartment:70101] cytosol [Compartment:17906] mitochondrial outer membrane [Compartment:17927] mitochondrial intermembrane space
created	[InstanceEdit:9911357] D'Eustachio, Peter, 2024-05-29
crossReference	[DatabaseIdentifier:9911369] RHEA:12662
edited	[InstanceEdit:9911357] D'Eustachio, Peter, 2024-05-29
input	[SimpleEntity:549207] CAR [mitochondrial intermembrane space] [SimpleEntity:200993] PALM-CoA [cytosol]
internalReviewed	[InstanceEdit:9911507] D'Eustachio, Peter, 2024-05-31
literatureReference	[LiteratureReference:549202] Functional studies of yeast-expressed human heart muscle carnitine palmitoyltransferase I
modified	[InstanceEdit:9911373] D'Eustachio, Peter, 2024-05-29 [InstanceEdit:9911506] D'Eustachio, Peter, 2024-05-31 [InstanceEdit:9911645] D'Eustachio, Peter, 2024-06-03 [InstanceEdit:9911646] D'Eustachio, Peter, 2024-06-03 [InstanceEdit:9917363] D'Eustachio, Peter, 2024-08-02 [InstanceEdit:9919307] D'Eustachio, Peter, 2024-08-20
name	CPT1B transfers PALM to CAR (R)-carnitine + hexadecanoyl-CoA => CoA + O-hexadecanoyl-(R)-carnitine palmitoyl-CoA + carnitine => palmitoylcarnitine + CoASH
output	[SimpleEntity:76194] CoA-SH [cytosol] [SimpleEntity:201034] L-PCAR [mitochondrial intermembrane space]
precedingEvent	[BlackBoxEvent:8949399] CAR translocates from the cytosol to the mitochondrial intermembrane space [Homo sapiens] [Reaction:165026] OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol [Homo sapiens] [Reaction:434382] ACSL3,4 ligates coenzyme A (CoA-SH) to a long chain fatty acid yielding fatty acyl-coenzyme A [Homo sapiens] [Reaction:434381] CD36 (FAT) translocates a long chain fatty acid from the extracellular region to the cytosol [Homo sapiens] [Reaction:5634100] FABP5 dissociates from RXRA:PPARD:atRA [Homo sapiens] [Reaction:5422942] RXRA:PPARD binds FABP5:atRA [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
regulatedBy	[NegativeRegulation:200418] Negative regulation by 'Mal-CoA [cytosol]'
regulationReference	[RegulationReference:9642880] Negative regulation by 'Mal-CoA [cytosol]' Structural model of a malonyl-CoA-binding site of carnitine octanoyltransferase and carnitine palmitoyltransferase I: mutational analysis of a malonyl-CoA affinity domain
releaseDate	2024-09-11
reviewed	[InstanceEdit:9917333] Hill, David P, 2024-08-02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9911372] R-HSA-9911362.1
summation	[Summation:9911368] Carnitine palmitoyl transferase 1B (CPT1B) associated with t...
(hasEvent)	[Pathway:200425] Carnitine shuttle [Homo sapiens]
(precedingEvent)	[Reaction:200424] Exchange of acylcarnitine and carnitine across the inner mitochondrial membrane [Homo sapiens]
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No pathways have been reviewed or authored by CPT1B transfers PALM to CAR (9911362)