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Details on Person In the nucleus, CIPC binds CLOCK in the CLOCK:BMAL1 complex ...

Class:Id	Summation:9911272
_displayName	In the nucleus, CIPC binds CLOCK in the CLOCK:BMAL1 complex ...
_timestamp	2025-01-07 15:04:40
created	[InstanceEdit:9911264] May, Bruce, 2024-05-28
literatureReference	[LiteratureReference:9911281] CIPC is a mammalian circadian clock protein without invertebrate homologues [LiteratureReference:9911256] Inactivation of Cipc alters the expression of Per1 but not circadian rhythms in mice [LiteratureReference:549461] Roles of CLOCK phosphorylation in suppression of E-box-dependent transcription
modified	[InstanceEdit:9934287] May, Bruce, 2025-01-07
text	In the nucleus, CIPC binds CLOCK in the CLOCK:BMAL1 complex (inferred from mouse homologs in Zhao et al. 2007), enhances phosphorylation of CLOCK (inferred from mouse homologs in Yoshitane et al. 2009), and represses transcriptional activation of the PER1 gene by CLOCK:BMAL1 (inferred from mouse homologs in Zhao et al. 2007, Qu et al. 2015).
(summation)	[BlackBoxEvent:9909561] Phosphorylated BMAL1:CLOCK,NPAS2 and coactivators positively regulate expression of Period-1 (PER1) [Homo sapiens]
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