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Details on Person DEC1 (BLHLHE40) negatively regulates transcription of DEC2 (...
| Class:Id | Summation:9910781 |
|---|---|
| _displayName | DEC1 (BLHLHE40) negatively regulates transcription of DEC2 (... |
| _timestamp | 2024-05-20 08:18:00 |
| created | [InstanceEdit:9910783] May, Bruce, 2024-05-20 |
| literatureReference | [LiteratureReference:9909558] Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1 [LiteratureReference:9909537] DNA binding, but not interaction with Bmal1, is responsible for DEC1-mediated transcription regulation of the circadian gene mPer1 |
| text | DEC1 (BLHLHE40) negatively regulates transcription of DEC2 (BHLHE41) by inhibiting BMAL1:CLOCK bound to the DEC2 promoter (Li et al. 2003). The mechanism of inhibition is incompletely characterized. DEC1 may bind the BMAL1:CLOCK heterodimer (Sato et al. 2004) or may compete with BMAL1:CLOCK for occupancy of the E-box in the promoter of DEC2 (inferred from mouse homologs in Li et al. 2004). |
| (summation) | [BlackBoxEvent:9909566] Expression of DEC2 (BHLHE41, BHLHB3) (update) [Homo sapiens] |
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No pathways have been reviewed or authored by DEC1 (BLHLHE40) negatively regulates transcription of DEC2 (... (9910781)
