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Details on Person UniProt:Q99460 PSMD1
| Class:Id | ReferenceGeneProduct:99098 |
|---|---|
| _chainChangeLog | chain:1-953 added on Fri February 6 2015 |
| _displayName | UniProt:Q99460 PSMD1 |
| _timestamp | 2024-11-03 19:53:25 |
| chain | chain:1-953 |
| checksum | B8682146082D21FA |
| comment | FUNCTION Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.SUBUNIT Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases and few additional components including PSMD1 (PubMed:27342858, PubMed:27428775). Interacts with ADRM1 (PubMed:16906146, PubMed:16990800). Interacts with ZFAND1 (PubMed:29804830).INTERACTION Belongs to the proteasome subunit S1 family.SEQUENCE CAUTION Contaminating sequence. Potential poly-A sequence.SEQUENCE CAUTION Contaminating sequence. Potential poly-A sequence.SEQUENCE CAUTION Contaminating sequence. Potential poly-A sequence.SEQUENCE CAUTION Contaminating sequence. Potential poly-A sequence.SEQUENCE CAUTION Contaminating sequence. Potential poly-A sequence.SEQUENCE CAUTION Contaminating sequence. Potential poly-A sequence. |
| description | recommendedName: 26S proteasome non-ATPase regulatory subunit 1 alternativeName: 26S proteasome regulatory subunit RPN2 alternativeName: 26S proteasome regulatory subunit S1 alternativeName: 26S proteasome subunit p112 |
| geneName | PSMD1 |
| identifier | Q99460 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Phosphoprotein Proteasome Proteomics identification Reference proteome Repeat |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | PSMD1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8958517] ENSEMBL:ENSG00000173692 PSMD1 [Homo sapiens] |
| secondaryIdentifier | PSMD1_HUMAN B8ZZH9 Q24JU0 Q53TI2 Q6GMU5 Q6P2P4 Q6PJM7 Q6PKG9 Q86VU1 Q8IV79 |
| sequenceLength | 953 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:152509] UniProt:Q99460-2 PSMD1 [Homo sapiens] [ReferenceIsoform:413140] UniProt:Q99460-1 PSMD1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:68786] PSMD1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:174348] PSMD1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:6798741] PSMD1 [azurophil granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:6806194] PSMD1 [extracellular region] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q99460 PSMD1 (99098)
