Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person NFE2L2 binding to CD274 gene

Class:IdReaction:9909652
_displayNameNFE2L2 binding to CD274 gene
_doReleaseTRUE
_timestamp2025-08-26 07:57:33
authored[InstanceEdit:9964122] Hung, Mien-Chie, Yamaguchi, Hirohito, 2025-08-26
[InstanceEdit:9927358] Tiwari, Krishna, 2024-11-05
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9909599] Tiwari, Krishna, 2024-05-14
edited[InstanceEdit:9962761] Gillespie, Marc E, 2025-08-08
input[EntityWithAccessionedSequence:9701419] CD274 gene [nucleoplasm] [Homo sapiens]
[Complex:9760062] p-AcK-NFE2L2:CREBBP, EP300 [nucleoplasm] [Homo sapiens]
internalReviewed[InstanceEdit:9914713] D'Eustachio, Peter, 2024-06-26
isChimericFALSE
literatureReference[LiteratureReference:9912058] Tumor-immune microenvironment and NRF2 associate with clinical efficacy of PD-1 blockade combined with chemotherapy in lung squamous cell carcinoma
[LiteratureReference:9912118] The Impact of Nrf2 Silencing on Nrf2-PD-L1 Axis to Overcome Oxaliplatin Resistance and Migration in Colon Cancer Cells
[LiteratureReference:9912067] Targeting the upstream transcriptional activator of PD-L1 as an alternative strategy in melanoma therapy
modified[InstanceEdit:9909704] Tiwari, Krishna, 2024-05-14
[InstanceEdit:9912117] Tiwari, Krishna, 2024-06-06
[InstanceEdit:9918017] Tiwari, Krishna, 2024-08-14
[InstanceEdit:9929193] Tiwari, Krishna, 2024-11-21
[InstanceEdit:9963582] Gillespie, Marc E, 2025-08-14
[InstanceEdit:9964108] Gillespie, Marc E, 2025-08-19
[InstanceEdit:9964110] Gillespie, Marc E, 2025-08-19
[InstanceEdit:9964120] Gillespie, Marc E, 2025-08-19
[InstanceEdit:9964121] Gillespie, Marc E, 2025-08-19
[InstanceEdit:9964125] Gillespie, Marc E, 2025-08-19
[InstanceEdit:9965199] Matthews, Lisa, 2025-08-26
nameNFE2L2 binding to CD274 gene
output[Complex:9909613] NRF2:CD274 gene [nucleoplasm] [Homo sapiens]
precedingEvent
previousReviewStatus[ReviewStatus:9821383] three stars
releaseDate2025-09-18
reviewed[InstanceEdit:9964122] Hung, Mien-Chie, Yamaguchi, Hirohito, 2025-08-26
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9909679] R-HSA-9909652.1
summation[Summation:9912049] NFE2L2 (NRF2/(Nuclear Factor Erythroid 2–Related Factor 2) ...
(hasEvent)[Pathway:9909649] Regulation of PD-L1(CD274) transcription [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9909623] CD274 Transcription [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by NFE2L2 binding to CD274 gene (9909652)