Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person Trimethylation of CD274 gene promoter by EZH2

Class:Id	Reaction:9909631
_displayName	Trimethylation of CD274 gene promoter by EZH2
_doRelease	TRUE
_timestamp	2025-08-26 07:58:21
authored	[InstanceEdit:9964122] Hung, Mien-Chie, Yamaguchi, Hirohito, 2025-08-26 [InstanceEdit:9927358] Tiwari, Krishna, 2024-11-05
catalystActivity	[CatalystActivity:3240298] histone H3K27 methyltransferase activity of PRC2 (EZH2) Core [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9909599] Tiwari, Krishna, 2024-05-14
edited	[InstanceEdit:9962761] Gillespie, Marc E, 2025-08-08
input	[Complex:9909625] PRC2(EZH2) Core:Nucleosome:CD274 gene promoter [nucleoplasm] [Homo sapiens] [SimpleEntity:77087] AdoMet [nucleoplasm] [SimpleEntity:77087] AdoMet [nucleoplasm] [SimpleEntity:77087] AdoMet [nucleoplasm] [SimpleEntity:77087] AdoMet [nucleoplasm] [SimpleEntity:77087] AdoMet [nucleoplasm] [SimpleEntity:77087] AdoMet [nucleoplasm]
internalReviewed	[InstanceEdit:9914713] D'Eustachio, Peter, 2024-06-26
isChimeric	FALSE
literatureReference	[LiteratureReference:9912068] EZH2 negatively regulates PD-L1 expression in hepatocellular carcinoma [LiteratureReference:9912120] EZH2 inhibition activates a dsRNA-STING-interferon stress axis that potentiates response to PD-1 checkpoint blockade in prostate cancer
modified	[InstanceEdit:9909704] Tiwari, Krishna, 2024-05-14 [InstanceEdit:9912244] Tiwari, Krishna, 2024-06-06 [InstanceEdit:9912800] Tiwari, Krishna, 2024-06-10 [InstanceEdit:9925929] Tiwari, Krishna, 2024-10-28 [InstanceEdit:9929193] Tiwari, Krishna, 2024-11-21 [InstanceEdit:9963582] Gillespie, Marc E, 2025-08-14 [InstanceEdit:9964108] Gillespie, Marc E, 2025-08-19 [InstanceEdit:9964110] Gillespie, Marc E, 2025-08-19 [InstanceEdit:9964120] Gillespie, Marc E, 2025-08-19 [InstanceEdit:9964121] Gillespie, Marc E, 2025-08-19 [InstanceEdit:9964125] Gillespie, Marc E, 2025-08-19 [InstanceEdit:9965199] Matthews, Lisa, 2025-08-26
name	Trimethylation of CD274 gene promoter by EZH2
output	[Complex:9909637] PRC2(EZH2) Core:H3K27me3 Nucleosome:CD274 gene [nucleoplasm] [Homo sapiens] [SimpleEntity:77502] AdoHcy [nucleoplasm] [SimpleEntity:77502] AdoHcy [nucleoplasm] [SimpleEntity:77502] AdoHcy [nucleoplasm] [SimpleEntity:77502] AdoHcy [nucleoplasm] [SimpleEntity:77502] AdoHcy [nucleoplasm] [SimpleEntity:77502] AdoHcy [nucleoplasm]
precedingEvent	[Reaction:9909611] PRC2(EZH2) core binding to CD274 gene promoter [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-09-18
reviewed	[InstanceEdit:9964122] Hung, Mien-Chie, Yamaguchi, Hirohito, 2025-08-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9909691] R-HSA-9909631.1
summation	[Summation:9912235] EZH2 binds to CD274 promoter and induces methylation of CD27...
(hasEvent)	[Pathway:9909649] Regulation of PD-L1(CD274) transcription [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9909623] CD274 Transcription [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by Trimethylation of CD274 gene promoter by EZH2 (9909631)