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Details on Person CD274 Transcription

Class:Id	BlackBoxEvent:9909623
_displayName	CD274 Transcription
_doRelease	TRUE
_timestamp	2025-08-26 07:56:13
authored	[InstanceEdit:9964122] Hung, Mien-Chie, Yamaguchi, Hirohito, 2025-08-26 [InstanceEdit:9927358] Tiwari, Krishna, 2024-11-05
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9909599] Tiwari, Krishna, 2024-05-14
edited	[InstanceEdit:9962761] Gillespie, Marc E, 2025-08-08
input	[EntityWithAccessionedSequence:9701419] CD274 gene [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9914713] D'Eustachio, Peter, 2024-06-26
isChimeric	FALSE
literatureReference	[LiteratureReference:9912228] PD-L1: expression regulation [LiteratureReference:9912234] Mechanisms Controlling PD-L1 Expression in Cancer [LiteratureReference:9912160] Mechanisms regulating PD-L1 expression in cancers and associated opportunities for novel small-molecule therapeutics [LiteratureReference:9912147] PD-1/PD-L1 axis regulation in cancer therapy: The role of long non-coding RNAs and microRNAs [LiteratureReference:9912250] Regulation of PD-L1 expression in cancer and clinical implications in immunotherapy
modified	[InstanceEdit:9909704] Tiwari, Krishna, 2024-05-14 [InstanceEdit:9911970] Tiwari, Krishna, 2024-06-06 [InstanceEdit:9912800] Tiwari, Krishna, 2024-06-10 [InstanceEdit:9929193] Tiwari, Krishna, 2024-11-21 [InstanceEdit:9963582] Gillespie, Marc E, 2025-08-14 [InstanceEdit:9964108] Gillespie, Marc E, 2025-08-19 [InstanceEdit:9964110] Gillespie, Marc E, 2025-08-19 [InstanceEdit:9964120] Gillespie, Marc E, 2025-08-19 [InstanceEdit:9964121] Gillespie, Marc E, 2025-08-19 [InstanceEdit:9964125] Gillespie, Marc E, 2025-08-19 [InstanceEdit:9965199] Matthews, Lisa, 2025-08-26
name	CD274 Transcription
output	[EntityWithAccessionedSequence:9909617] CD274 mRNA [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9909610] AP-1 binding to CD274 gene [Homo sapiens] [Reaction:450292] Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer. [Homo sapiens] [Reaction:9909594] ATF3 binding to CD274 gene [Homo sapiens] [BlackBoxEvent:1791173] Expression of ATF3 [Homo sapiens] [Reaction:9909635] BRD4 binding to CD274 gene chromatin [Homo sapiens] [Reaction:9909632] CTNNB1 binding to CD274 gene [Homo sapiens] [Reaction:3299569] Beta-catenin displaces TLE:HDAC1 from TCF/LEF [Homo sapiens] [BlackBoxEvent:201669] Beta-catenin translocates to the nucleus [Homo sapiens] [Reaction:9909618] HIF1A,EPAS1 binding to CD274 gene [Homo sapiens] [Reaction:9909608] IRF1 binding to CD274 promoter [Homo sapiens] [BlackBoxEvent:8951289] Expression of Interferon regulatory factor 1 [Homo sapiens] [Reaction:9909602] MYC,MYCN binding to CD274 gene [Homo sapiens] [BlackBoxEvent:9634348] MYC mRNA is translated to yield MYC protein [Homo sapiens] [BlackBoxEvent:5687113] MYC mRNA translation is negatively regulated by miR-34B and C [Homo sapiens] [Reaction:9909622] NFKB_complex binding to CD274 gene [Homo sapiens] [Reaction:168166] NF-kappa-B complex is transported from cytosol to nucleus [Homo sapiens] [BlackBoxEvent:2730894] NFKB1:RELA translocates from the cytosol to the nucleus [Homo sapiens] [Reaction:9909652] NFE2L2 binding to CD274 gene [Homo sapiens] [Reaction:9760082] NFE2L2 binds CREBBP,EP300 [Homo sapiens] [Reaction:9909657] STAT1 dimer binding to CD274 gene [Homo sapiens] [BlackBoxEvent:8987218] p-STAT1 dimer translocates from the cytosol to the nucleoplasm [Homo sapiens] [BlackBoxEvent:8985983] p-Y701-STAT1 dimer translocates from the cytosol to the nucleus [Homo sapiens] [Reaction:9909609] STAT3 dimer binding to CD274 gene [Homo sapiens] [BlackBoxEvent:9701529] p-Y705, p-S727 STAT3 dimer translocates to the nucleus [Homo sapiens] [BlackBoxEvent:6784763] p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm [Homo sapiens] [Reaction:9909654] YAP1/TAZ binding to CD274 gene [Homo sapiens] [Reaction:2032781] WWTR1 (TAZ) binds TEAD [Homo sapiens] [Reaction:9909628] Trimethylation of CD274 gene chromatin by MLL1/3 complex [Homo sapiens] [Reaction:9909646] MLL1,MLL3 complex binding to CD274 gene chromatin [Homo sapiens] [Reaction:9909631] Trimethylation of CD274 gene promoter by EZH2 [Homo sapiens] [Reaction:9909611] PRC2(EZH2) core binding to CD274 gene promoter [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
regulatedBy	[PositiveGeneExpressionRegulation:9909616] Positive gene expression regulation by 'STAT3_dimer:CD274 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:9909629] Positive gene expression regulation by 'STAT1_dimer:CD274 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:9909638] Positive gene expression regulation by 'IRF1:CD274 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:9909612] Positive gene expression regulation by 'NFKB_Complex:CD274 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:9909656] Positive gene expression regulation by 'MYC,MYCN:CD274 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:9909639] Positive gene expression regulation by 'HIF1A,EPAS1:CD274 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:9909658] Positive gene expression regulation by 'NRF2:CD274 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:9909634] Positive gene expression regulation by 'ATF3:CD274 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:9909621] Positive gene expression regulation by 'CTNNB1:CD274 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:9909644] Positive gene expression regulation by 'AP-1:CD274 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:9909624] Positive gene expression regulation by 'YAP1:WWNT1:TEADs:CD274 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:9909643] Positive gene expression regulation by 'BRD4:CD274 gene chromatin [nucleoplasm]' [PositiveGeneExpressionRegulation:9909640] Positive gene expression regulation by 'MLL1,MLL3_complex:CD274 gene H3K4me3 chromatin [nucleoplasm]' [NegativeGeneExpressionRegulation:9909650] Negative gene expression regulation by 'PRC2(EZH2) Core:H3K27me3 Nucleosome:CD274 gene [nucleoplasm]'
regulationReference	[RegulationReference:9912801] Positive gene expression regulation by 'STAT3_dimer:CD274 gene [nucleoplasm]' Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1) [RegulationReference:9912824] Positive gene expression regulation by 'STAT1_dimer:CD274 gene [nucleoplasm]' IFNγ-induced PD-L1 expression in ovarian cancer cells is regulated by JAK1, STAT1 and IRF1 signaling [RegulationReference:9912821] Positive gene expression regulation by 'IRF1:CD274 gene [nucleoplasm]' IFNγ-induced PD-L1 expression in ovarian cancer cells is regulated by JAK1, STAT1 and IRF1 signaling [RegulationReference:9912809] Positive gene expression regulation by 'NFKB_Complex:CD274 gene [nucleoplasm]' NF-κB plays a key role in inducing CD274 expression in human monocytes after lipopolysaccharide treatment [RegulationReference:9912802] Positive gene expression regulation by 'MYC,MYCN:CD274 gene [nucleoplasm]' C-Myc regulates PD-L1 expression in esophageal squamous cell carcinoma [RegulationReference:9912828] Positive gene expression regulation by 'HIF1A,EPAS1:CD274 gene [nucleoplasm]' The relationship between expression of PD-L1 and HIF-1α in glioma cells under hypoxia [RegulationReference:9912806] Positive gene expression regulation by 'NRF2:CD274 gene [nucleoplasm]' Tumor-immune microenvironment and NRF2 associate with clinical efficacy of PD-1 blockade combined with chemotherapy in lung squamous cell carcinoma [RegulationReference:9912803] Positive gene expression regulation by 'ATF3:CD274 gene [nucleoplasm]' ADORA1 Inhibition Promotes Tumor Immune Evasion by Regulating the ATF3-PD-L1 Axis [RegulationReference:9912798] Positive gene expression regulation by 'CTNNB1:CD274 gene [nucleoplasm]' β-Catenin induces transcriptional expression of PD-L1 to promote glioblastoma immune evasion [RegulationReference:9912812] Positive gene expression regulation by 'AP-1:CD274 gene [nucleoplasm]' Constitutive AP-1 activity and EBV infection induce PD-L1 in Hodgkin lymphomas and posttransplant lymphoproliferative disorders: implications for targeted therapy [RegulationReference:9912805] Positive gene expression regulation by 'YAP1:WWNT1:TEADs:CD274 gene [nucleoplasm]' The Hippo Pathway Component TAZ Promotes Immune Evasion in Human Cancer through PD-L1 [RegulationReference:9912816] Positive gene expression regulation by 'BRD4:CD274 gene [nucleoplasm]' BRD4 inhibition suppresses PD-L1 expression in triple-negative breast cancer [RegulationReference:9912815] Positive gene expression regulation by 'MLL1,MLL3_complex:CD274 gene H3K4me3 chromatin [nucleoplasm]' The MLL1-H3K4me3 Axis-Mediated PD-L1 Expression and Pancreatic Cancer Immune Evasion [RegulationReference:9912829] Negative gene expression regulation by 'PRC2(EZH2) Core:H3K27me3 Nucleosome:CD274 gene [nucleoplasm]' EZH2 negatively regulates PD-L1 expression in hepatocellular carcinoma
releaseDate	2025-09-18
reviewed	[InstanceEdit:9964122] Hung, Mien-Chie, Yamaguchi, Hirohito, 2025-08-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9909690] R-HSA-9909623.1
summation	[Summation:9912811] The transcriptional regulation of CD274 (PD-L1/programmed de...
(hasEvent)	[Pathway:9909649] Regulation of PD-L1(CD274) transcription [Homo sapiens]
(precedingEvent)	[Reaction:9924908] CD274 mRNA binds miR-93 RISC [Homo sapiens] [Reaction:9924921] CD274 mRNA binds miR-34 RISC [Homo sapiens] [Reaction:9924968] CD274 mRNA binds miR-429 RISC [Homo sapiens] [Reaction:9925087] CD274 mRNA binds miR-138-5p RISC [Homo sapiens] [Reaction:9925095] CD274 mRNA binds miR-340 RISC [Homo sapiens] [Reaction:9925158] CD274 mRNA binds miR-152 RISC [Homo sapiens] [Reaction:9925159] CD274 mRNA binds miR-140 RISC [Homo sapiens] [BlackBoxEvent:9925190] CD274 translation [Homo sapiens] [Reaction:9925246] CD274 mRNA binds miR-Let7-a1 RISC [Homo sapiens] [Reaction:9925270] CD274 mRNA binds miR-148a-3p RISC [Homo sapiens] List all 13 refering instances
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No pathways have been reviewed or authored by CD274 Transcription (9909623)