Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person PRC2(EZH2) core binding to CD274 gene promoter

Class:Id	Reaction:9909611
_displayName	PRC2(EZH2) core binding to CD274 gene promoter
_doRelease	TRUE
_timestamp	2025-08-26 07:57:43
authored	[InstanceEdit:9964122] Hung, Mien-Chie, Yamaguchi, Hirohito, 2025-08-26 [InstanceEdit:9927358] Tiwari, Krishna, 2024-11-05
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9909599] Tiwari, Krishna, 2024-05-14
edited	[InstanceEdit:9962761] Gillespie, Marc E, 2025-08-08
input	[Complex:212285] PRC2 (EZH2) Core [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9701419] CD274 gene [nucleoplasm] [Homo sapiens] [Complex:427402] Nucleosome [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9914713] D'Eustachio, Peter, 2024-06-26
isChimeric	FALSE
literatureReference	[LiteratureReference:9912068] EZH2 negatively regulates PD-L1 expression in hepatocellular carcinoma [LiteratureReference:9912120] EZH2 inhibition activates a dsRNA-STING-interferon stress axis that potentiates response to PD-1 checkpoint blockade in prostate cancer
modified	[InstanceEdit:9909704] Tiwari, Krishna, 2024-05-14 [InstanceEdit:9912117] Tiwari, Krishna, 2024-06-06 [InstanceEdit:9929193] Tiwari, Krishna, 2024-11-21 [InstanceEdit:9963582] Gillespie, Marc E, 2025-08-14 [InstanceEdit:9964108] Gillespie, Marc E, 2025-08-19 [InstanceEdit:9964110] Gillespie, Marc E, 2025-08-19 [InstanceEdit:9964120] Gillespie, Marc E, 2025-08-19 [InstanceEdit:9964121] Gillespie, Marc E, 2025-08-19 [InstanceEdit:9964125] Gillespie, Marc E, 2025-08-19 [InstanceEdit:9965199] Matthews, Lisa, 2025-08-26
name	PRC2(EZH2) core binding to CD274 gene promoter
output	[Complex:9909625] PRC2(EZH2) Core:Nucleosome:CD274 gene promoter [nucleoplasm] [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-09-18
reviewed	[InstanceEdit:9964122] Hung, Mien-Chie, Yamaguchi, Hirohito, 2025-08-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9909663] R-HSA-9909611.1
summation	[Summation:9912063] EZH2 (Enhancer of Zeste Homolog 2) regulates CD274 (PD-L1) t...
(hasEvent)	[Pathway:9909649] Regulation of PD-L1(CD274) transcription [Homo sapiens]
(precedingEvent)	[Reaction:9909631] Trimethylation of CD274 gene promoter by EZH2 [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by PRC2(EZH2) core binding to CD274 gene promoter (9909611)