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Details on Person Expression of DEC1 (BHLHE40, BHLHB2) (update)

Class:Id	BlackBoxEvent:9909567
_displayName	Expression of DEC1 (BHLHE40, BHLHB2) (update)
_timestamp	2024-10-21 08:09:43
authored	[InstanceEdit:9909554] May, Bruce, 2024-05-14
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9909554] May, Bruce, 2024-05-14
edited	[InstanceEdit:9909554] May, Bruce, 2024-05-14
inferredFrom	[BlackBoxEvent:9909548] Expression of Dec1 (Bhlhe40, Bhlhb2) (update) [Mus musculus]
input	[EntityWithAccessionedSequence:5641211] BHLHE40 gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:879704] A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation [LiteratureReference:9909558] Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1
modified	[InstanceEdit:9910784] May, Bruce, 2024-05-20 [InstanceEdit:9925663] May, Bruce, 2024-10-21
name	Expression of DEC1 (BHLHE40, BHLHB2) (update)
output	[EntityWithAccessionedSequence:879741] BHLHE40 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:5663170] p-S90-BMAL1:p-T451,T461-CLOCK binds BHLHE40 gene [Homo sapiens] [BlackBoxEvent:9920665] p-S90-BMAL1:p-T451,T461-CLOCK translocates from the cytosol to the nucleus [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:879830] Positive gene expression regulation by 'p-S90-BMAL1:p-T451,T461-CLOCK:BHLHE40 gene [nucleoplasm]' [NegativeGeneExpressionRegulation:9909568] Negative gene expression regulation by 'BHLHE40 dimer [nucleoplasm]'
regulationReference	[RegulationReference:9642593] Positive gene expression regulation by 'p-BMAL1:p-CLOCK,NPAS2:BHLHE40 gene [nucleoplasm]' A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation [RegulationReference:9909562] Negative gene expression regulation by 'BHLHE40 dimer [nucleoplasm]' Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9909572] R-HSA-9909567.1
summation	[Summation:879732] The DEC1 (BHLHE40, BHLHB2) gene is transcribed to yield mRNA... [Summation:9910782] DEC1 (BLHLHE40) negatively regulates its own transcription b...
(hasEvent)	[Pathway:9934865] Circadian clock update - do not release [Homo sapiens]
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No pathways have been reviewed or authored by Expression of DEC1 (BHLHE40, BHLHB2) (update) (9909567)