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Details on Person p-S-CRY:p-S-PER:CSNK1D,E complex translocates from the cytosol to the nucleus

Class:Id	BlackBoxEvent:9909565
_displayName	p-S-CRY:p-S-PER:CSNK1D,E complex translocates from the cytosol to the nucleus
_doRelease	TRUE
_timestamp	2025-02-26 18:02:07
authored	[InstanceEdit:9909554] May, Bruce, 2024-05-14
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:9909554] May, Bruce, 2024-05-14
edited	[InstanceEdit:9909554] May, Bruce, 2024-05-14
inferredFrom	[BlackBoxEvent:9909538] Phosphorylated Cry:Per:Csnk1d,e complex translocates from the cytosol to the nucleus [Mus musculus]
input	[Complex:9909377] p-S-CRY1:p-S-CRY2:p-S-PER1:p-7S-PER2:p-S-PER3:CSNK1E,CSNK1D [cytosol] [Homo sapiens]
internalReviewed	[InstanceEdit:9936833] Matthews, Lisa, 2025-01-27
isChimeric	FALSE
modified	[InstanceEdit:9922287] May, Bruce, 2024-09-21 [InstanceEdit:9923060] May, Bruce, 2024-09-29 [InstanceEdit:9930079] May, Bruce, 2024-12-02 [InstanceEdit:9933409] May, Bruce, 2024-12-29 [InstanceEdit:9935064] May, Bruce, 2025-01-12 [InstanceEdit:9936865] May, Bruce, 2025-01-27 [InstanceEdit:9938453] May, Bruce, 2025-02-14 [InstanceEdit:9938697] May, Bruce, 2025-02-18 [InstanceEdit:9939392] May, Bruce, 2025-02-26
name	p-S-CRY:p-S-PER:CSNK1D,E complex translocates from the cytosol to the nucleus
output	[Complex:9909556] p-S-CRY1:p-S-CRY2:p-S-PER1:p-7S-PER2:p-S-PER3:CSNK1D,E [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9909369] CSNK1E,CSNK1D phosphorylate CRY and PER proteins [Homo sapiens] [BlackBoxEvent:9909392] Formation of CRY:PER:Kinase complex [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-03-26
reviewed	[InstanceEdit:9938389] Sancar, Aziz, 2025-02-14 [InstanceEdit:9938694] Albrecht, Urs, 2025-02-18
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9909571] R-HSA-9909565.1
summation	[Summation:9930076] Cryptochrome (CRY1, CRY2) proteins bind Period (PER1, PER2, ...
(hasEvent)	[Pathway:9931530] Phosphorylation and nuclear translocation of the CRY:PER:kinase complex [Homo sapiens]
(precedingEvent)	[Reaction:9922269] p-S-CRY:p-S-PER:CSNK1D,E binds p-S90,Ac-K538-BMAL1:p-2T,3S-CLOCK:target gene [Homo sapiens] [BlackBoxEvent:9932512] FBXL3:CUL1:SKP1:RBX1 ubiquitinylates phosphorylated CRY1,2 [Homo sapiens] [Reaction:9932535] FBXL3:CUL1:SKP1:RBX1 binds phosphorylated CRY1,2 [Homo sapiens] [Reaction:9933128] DDB1:CUL4:RBX1:DTL binds phosphorylated (?) CRY1 [Homo sapiens]
(replacementInstances)	[_Deleted:9938729] Deletion of instance: 549385
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No pathways have been reviewed or authored by p-S-CRY:p-S-PER:CSNK1D,E complex translocates from the cytosol to the nucleus (9909565)