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Details on Person Phosphorylated BMAL1:CLOCK,NPAS2 and coactivators positively regulate expression of Period-1 (PER1)
Class:Id BlackBoxEvent:9909561 _displayName Phosphorylated BMAL1:CLOCK,NPAS2 and coactivators positively regulate expression of Period-1 (PER1) _doRelease TRUE _timestamp 2025-02-18 21:07:07 authored [InstanceEdit:9909554] May, Bruce, 2024-05-14 compartment [Compartment:7660] nucleoplasm [Compartment:70101] cytosol created [InstanceEdit:9909554] May, Bruce, 2024-05-14 edited [InstanceEdit:9909554] May, Bruce, 2024-05-14 inferredFrom
input [EntityWithAccessionedSequence:5641209] PER1 gene [nucleoplasm] [Homo sapiens] internalReviewed [InstanceEdit:9936833] Matthews, Lisa, 2025-01-27 isChimeric FALSE literatureReference [LiteratureReference:508324] Activation of human period-1 by PKA or CLOCK/BMAL1 is conferred by separate signal transduction pathways [LiteratureReference:400293] Phosphorylation of clock protein PER1 regulates its circadian degradation in normal human fibroblasts [LiteratureReference:549441] The human and mouse Period1 genes: five well-conserved E-boxes additively contribute to the enhancement of mPer1 transcription [LiteratureReference:9930029] Circadian patterns of gene expression in the human brain and disruption in major depressive disorder modified [InstanceEdit:9910806] May, Bruce, 2024-05-21 [InstanceEdit:9911300] May, Bruce, 2024-05-28 [InstanceEdit:9923060] May, Bruce, 2024-09-29 [InstanceEdit:9926648] May, Bruce, 2024-11-01 [InstanceEdit:9929342] May, Bruce, 2024-11-24 [InstanceEdit:9930033] May, Bruce, 2024-11-30 [InstanceEdit:9933409] May, Bruce, 2024-12-29 [InstanceEdit:9933436] May, Bruce, 2024-12-30 [InstanceEdit:9935064] May, Bruce, 2025-01-12 [InstanceEdit:9936399] May, Bruce, 2025-01-22 [InstanceEdit:9936865] May, Bruce, 2025-01-27 [InstanceEdit:9938391] May, Bruce, 2025-02-14 [InstanceEdit:9938517] May, Bruce, 2025-02-17 [InstanceEdit:9938697] May, Bruce, 2025-02-18 name Phosphorylated BMAL1:CLOCK,NPAS2 and coactivators positively regulate expression of Period-1 (PER1) output [EntityWithAccessionedSequence:400373] PER1 [cytosol] [Homo sapiens] precedingEvent
previousReviewStatus [ReviewStatus:9821383] three stars regulatedBy [PositiveGeneExpressionRegulation:9922983] Positive gene expression regulation by 'p-S90-BMAL1:p-T451,T461-CLOCK,p-NPAS2:CREBBP:KMT2A:PER1 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:5656481] Positive gene expression regulation by 'p-CREB:CRTC1:PER1 gene [nucleoplasm]' [NegativeGeneExpressionRegulation:5656522] Negative gene expression regulation by 'SIK1 [nucleoplasm]' [PositiveGeneExpressionRegulation:8878887] Positive gene expression regulation by 'RBM4:PER1 mRNA [cytosol]' [NegativeGeneExpressionRegulation:8878902] Negative gene expression regulation by 'CREM:PER1 gene [nucleoplasm]' [NegativeGeneExpressionRegulation:9909568] Negative gene expression regulation by 'BHLHE40 dimer [nucleoplasm]' [NegativeGeneExpressionRegulation:9911268] Negative gene expression regulation by 'p-S-BMAL1:p-S-CLOCK:CIPC [nucleoplasm]' regulationReference [RegulationReference:9641218] Positive gene expression regulation by 'p-CREB:CRTC1:PER1 gene [nucleoplasm]' The CRTC1-SIK1 pathway regulates entrainment of the circadian clock [RegulationReference:9641541] Positive gene expression regulation by 'RBM4:PER1 mRNA [cytosol]' LARK activates posttranscriptional expression of an essential mammalian clock protein, PERIOD1 [RegulationReference:9641613] Negative gene expression regulation by 'CREM:PER1 gene [nucleoplasm]' Inducible cAMP early repressor regulates the Period 1 gene of the hepatic and adrenal clocks [RegulationReference:9641782] Negative gene expression regulation by 'SIK1 [nucleoplasm]' The CRTC1-SIK1 pathway regulates entrainment of the circadian clock [RegulationReference:9926601] Positive gene expression regulation by 'p-S90-BMAL1:p-T451,T461-CLOCK,p-NPAS2:CREBBP:KMT2A:PER1 gene [nucleoplasm]' Activation of human period-1 by PKA or CLOCK/BMAL1 is conferred by separate signal transduction pathways releaseDate 2025-03-26 reviewed [InstanceEdit:9938389] Sancar, Aziz, 2025-02-14 [InstanceEdit:9938694] Albrecht, Urs, 2025-02-18 reviewStatus [ReviewStatus:9821382] five stars species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:9909582] R-HSA-9909561.1 structureModified [InstanceEdit:9911300] May, Bruce, 2024-05-28 [InstanceEdit:9923060] May, Bruce, 2024-09-29 summation [Summation:9929290] Phosphorylated BMAL1:CLOCK heterodimers bound to four (infer... [Summation:8878897] As inferred from mouse homologs, the ICER isoform of CREM ( ... [Summation:8878889] As inferred from mouse homologs, RBM4 (hLARK) binds the 3' U... [Summation:9910802] DEC1 (BHLHE40) negatively regulates transcription of PER1 by... [Summation:9911272] In the nucleus, CIPC binds CLOCK in the CLOCK:BMAL1 complex ... (hasEvent) [Pathway:9931510] Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes [Homo sapiens] (precedingEvent) [BlackBoxEvent:9909392] Formation of CRY:PER:Kinase complex [Homo sapiens] (replacementInstances) [_Deleted:9938769] Deletion of instance: 549533
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