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Details on Person Phosphorylated Cry:Per:Csnk1d,e complex translocates from the cytosol to the nucleus

Class:Id	BlackBoxEvent:9909538
_displayName	Phosphorylated Cry:Per:Csnk1d,e complex translocates from the cytosol to the nucleus
_doRelease	TRUE
_timestamp	2025-02-28 00:48:33
authored	[InstanceEdit:9909554] May, Bruce, 2024-05-14
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:9909554] May, Bruce, 2024-05-14
edited	[InstanceEdit:9909554] May, Bruce, 2024-05-14
input	[Complex:9909375] p-S-Cry1:p-S-Cry2:p-S-Per1:p-7S-Per2:p-S-Per3:Csnk1e,Csnk1d [cytosol] [Mus musculus]
internalReviewed	[InstanceEdit:9936833] Matthews, Lisa, 2025-01-27
isChimeric	FALSE
literatureReference	[LiteratureReference:549540] mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop [LiteratureReference:421281] The circadian regulatory proteins BMAL1 and cryptochromes are substrates of casein kinase Iepsilon [LiteratureReference:508611] Essential roles of CKIdelta and CKIepsilon in the mammalian circadian clock [LiteratureReference:549358] Nucleocytoplasmic shuttling and mCRY-dependent inhibition of ubiquitylation of the mPER2 clock protein [LiteratureReference:508630] Nuclear entry of the circadian regulator mPER1 is controlled by mammalian casein kinase I epsilon [LiteratureReference:400264] Nuclear export of mammalian PERIOD proteins [LiteratureReference:9909363] Macromolecular Assemblies of the Mammalian Circadian Clock [LiteratureReference:9909390] Analysis of mammalian circadian clock protein complexes over a circadian cycle [LiteratureReference:9929253] Dimerization and nuclear entry of mPER proteins in mammalian cells
modified	[InstanceEdit:9922287] May, Bruce, 2024-09-21 [InstanceEdit:9923060] May, Bruce, 2024-09-29 [InstanceEdit:9929342] May, Bruce, 2024-11-24 [InstanceEdit:9930079] May, Bruce, 2024-12-02 [InstanceEdit:9933409] May, Bruce, 2024-12-29 [InstanceEdit:9935064] May, Bruce, 2025-01-12 [InstanceEdit:9936865] May, Bruce, 2025-01-27 [InstanceEdit:9938453] May, Bruce, 2025-02-14 [InstanceEdit:9938517] May, Bruce, 2025-02-17 [InstanceEdit:9938697] May, Bruce, 2025-02-18 [InstanceEdit:9939539] May, Bruce, 2025-02-28
name	Phosphorylated Cry:Per:Csnk1d,e complex translocates from the cytosol to the nucleus
output	[Complex:9909553] p-S-Cry1:p-S-Cry2:p-S-Per1:p-S-Per2:p-S-Per3:Csnk1e,Csnk1d [nucleoplasm] [Mus musculus]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-03-26
reviewed	[InstanceEdit:9938389] Sancar, Aziz, 2025-02-14 [InstanceEdit:9938694] Albrecht, Urs, 2025-02-18
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:9909577] R-MMU-9909538.1
summation	[Summation:9930077] Cryptochrome proteins (Cry1, Cry2) bind Period proteins (Per...
(inferredFrom)	[BlackBoxEvent:9909565] p-S-CRY:p-S-PER:CSNK1D,E complex translocates from the cytosol to the nucleus [Homo sapiens]
(replacementInstances)	[_Deleted:9939531] Deletion of instance: 549498
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