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Details on Person p-S90-BMAL1:p-T451,T461-CLOCK and coactivators bind the PER3 gene

Class:Id	Reaction:9909400
_displayName	p-S90-BMAL1:p-T451,T461-CLOCK and coactivators bind the PER3 gene
_doRelease	TRUE
_timestamp	2025-02-18 21:13:47
authored	[InstanceEdit:9909367] May, Bruce, 2024-05-11
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9909380] May, Bruce, 2024-05-13
edited	[InstanceEdit:9909367] May, Bruce, 2024-05-11
inferredFrom	[Reaction:9909388] p-S97-Bmal1:p-T451,T461-Clock and coactivators bind the Per3 gene [Mus musculus]
input	[EntityWithAccessionedSequence:9909379] PER3 gene [nucleoplasm] [Homo sapiens] [Complex:9920661] p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] [Homo sapiens] [Complex:9920661] p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] [Homo sapiens] [Complex:9920661] p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:193545] CREBBP [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:1183223] KMT2A [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9936833] Matthews, Lisa, 2025-01-27
isChimeric	FALSE
literatureReference	[LiteratureReference:9929328] Multiple circadian transcriptional elements cooperatively regulate cell-autonomous transcriptional oscillation of Period3, a mammalian clock gene
modified	[InstanceEdit:9920763] May, Bruce, 2024-09-03 [InstanceEdit:9929342] May, Bruce, 2024-11-24 [InstanceEdit:9936865] May, Bruce, 2025-01-27 [InstanceEdit:9938391] May, Bruce, 2025-02-14 [InstanceEdit:9938517] May, Bruce, 2025-02-17 [InstanceEdit:9938697] May, Bruce, 2025-02-18
name	p-S90-BMAL1:p-T451,T461-CLOCK and coactivators bind the PER3 gene
output	[Complex:9909389] p-S90-BMAL1:p-T451,T461-CLOCK:CREBBP:KMT2A:PER3 gene [nucleoplasm] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9920665] p-S90-BMAL1:p-T451,T461-CLOCK translocates from the cytosol to the nucleus [Homo sapiens] [Reaction:9912390] p-S90-BMAL1 binds p-T451,T461-CLOCK [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-03-26
reviewed	[InstanceEdit:9938389] Sancar, Aziz, 2025-02-14 [InstanceEdit:9938694] Albrecht, Urs, 2025-02-18
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9909410] R-HSA-9909400.1
structureModified	[InstanceEdit:9920763] May, Bruce, 2024-09-03 [InstanceEdit:9929342] May, Bruce, 2024-11-24
summation	[Summation:9929331] A dimer of phosphorylated BMAL1:CLOCK heterodimers binds adj...
(hasEvent)	[Pathway:9931510] Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9909374] Phosphorylated BMAL1:CLOCK and coactivators positively regulate expression of Period-3 (PER3) [Homo sapiens] [BlackBoxEvent:9920724] p-T451,T461-CLOCK is phosphorylated on serines-440,441,446 [Homo sapiens]
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No pathways have been reviewed or authored by p-S90-BMAL1:p-T451,T461-CLOCK and coactivators bind the PER3 gene (9909400)