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Details on Person Csnk1e,Csnk1d phosphorylate Cry and Per proteins

Class:IdReaction:9909394
_displayNameCsnk1e,Csnk1d phosphorylate Cry and Per proteins
_doReleaseTRUE
_timestamp2025-02-18 21:02:23
authored[InstanceEdit:9909367] May, Bruce, 2024-05-11
catalystActivity[CatalystActivity:9911561] protein serine/threonine kinase activity of Cry1:Cry2:Per1:Per2:Per3:Csnk1e,Csnk1d [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:9909380] May, Bruce, 2024-05-13
edited[InstanceEdit:9909367] May, Bruce, 2024-05-11
input[Complex:9909387] Cry1:Cry2:Per1:Per2:Per3:Csnk1e,Csnk1d [cytosol] [Mus musculus]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
internalReviewed[InstanceEdit:9936833] Matthews, Lisa, 2025-01-27
isChimericFALSE
literatureReference[LiteratureReference:508355] CKIepsilon/delta-dependent phosphorylation is a temperature-insensitive, period-determining process in the mammalian circadian clock
[LiteratureReference:508629] Direct association between mouse PERIOD and CKIepsilon is critical for a functioning circadian clock
[LiteratureReference:421294] Control of intracellular dynamics of mammalian period proteins by casein kinase I epsilon (CKIepsilon) and CKIdelta in cultured cells
[LiteratureReference:400336] Control of mammalian circadian rhythm by CKIepsilon-regulated proteasome-mediated PER2 degradation
[LiteratureReference:508630] Nuclear entry of the circadian regulator mPER1 is controlled by mammalian casein kinase I epsilon
[LiteratureReference:421298] Posttranslational mechanisms regulate the mammalian circadian clock
[LiteratureReference:421281] The circadian regulatory proteins BMAL1 and cryptochromes are substrates of casein kinase Iepsilon
[LiteratureReference:9922992] PER2 Differentially Regulates Clock Phosphorylation versus Transcription by Reciprocal Switching of CK1ε Activity
modified[InstanceEdit:9911591] May, Bruce, 2024-06-01
[InstanceEdit:9920763] May, Bruce, 2024-09-03
[InstanceEdit:9923060] May, Bruce, 2024-09-29
[InstanceEdit:9923960] May, Bruce, 2024-10-05
[InstanceEdit:9925663] May, Bruce, 2024-10-21
[InstanceEdit:9931013] May, Bruce, 2024-12-09
[InstanceEdit:9932107] May, Bruce, 2024-12-17
[InstanceEdit:9935064] May, Bruce, 2025-01-12
[InstanceEdit:9936865] May, Bruce, 2025-01-27
[InstanceEdit:9938453] May, Bruce, 2025-02-14
[InstanceEdit:9938517] May, Bruce, 2025-02-17
[InstanceEdit:9938697] May, Bruce, 2025-02-18
nameCsnk1e,Csnk1d phosphorylate Cry and Per proteins
output[Complex:9909375] p-S-Cry1:p-S-Cry2:p-S-Per1:p-7S-Per2:p-S-Per3:Csnk1e,Csnk1d [cytosol] [Mus musculus]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
previousReviewStatus[ReviewStatus:9821383] three stars
regulatedBy[PositiveRegulation:9925655] Positive regulation by 'CK2 [cytosol]'
[NegativeRegulation:9932078] Negative regulation by 'PP1 catalytic subunit [cytosol]'
regulationReference[RegulationReference:9925659] Positive regulation by 'CK2 [cytosol]' Involvement of the protein kinase CK2 in the regulation of mammalian circadian rhythms
[RegulationReference:9932091] Negative regulation by 'PP1 catalytic subunit [cytosol]' Protein phosphatase 1 (PP1) is a post-translational regulator of the mammalian circadian clock
releaseDate2025-03-26
reviewed[InstanceEdit:9938389] Sancar, Aziz, 2025-02-14
[InstanceEdit:9938694] Albrecht, Urs, 2025-02-18
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48892] Mus musculus
stableIdentifier[StableIdentifier:9909416] R-MMU-9909394.1
structureModified[InstanceEdit:9911591] May, Bruce, 2024-06-01
[InstanceEdit:9920763] May, Bruce, 2024-09-03
[InstanceEdit:9923960] May, Bruce, 2024-10-05
[InstanceEdit:9925663] May, Bruce, 2024-10-21
[InstanceEdit:9932107] May, Bruce, 2024-12-17
summation[Summation:9909391] In the cytosol the kinases casein kinase I delta (Csnk1d) an...
(inferredFrom)[Reaction:9909369] CSNK1E,CSNK1D phosphorylate CRY and PER proteins [Homo sapiens]
(replacementInstances)[_Deleted:9939514] Deletion of instance: 508627
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No pathways have been reviewed or authored by Csnk1e,Csnk1d phosphorylate Cry and Per proteins (9909394)
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