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Details on Person Formation of CRY:PER:Kinase complex

Class:Id	BlackBoxEvent:9909392
_displayName	Formation of CRY:PER:Kinase complex
_doRelease	TRUE
_timestamp	2025-02-26 18:01:50
authored	[InstanceEdit:9909380] May, Bruce, 2024-05-13
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9909380] May, Bruce, 2024-05-13
edited	[InstanceEdit:9909380] May, Bruce, 2024-05-13
inferredFrom	[BlackBoxEvent:9909360] Formation of Cry:Per:Kinase complex [Mus musculus]
input	[EntityWithAccessionedSequence:400247] CRY1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:400255] CRY2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:400373] PER1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:400323] PER3 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9920705] p-S396-PER2 [cytosol] [Homo sapiens] [DefinedSet:9933493] CSNK1D,CSNK1E [cytosol] [Homo sapiens]
internalReviewed	[InstanceEdit:9936833] Matthews, Lisa, 2025-01-27
isChimeric	FALSE
literatureReference	[LiteratureReference:508746] Phosphorylation and destabilization of human period I clock protein by human casein kinase I epsilon [LiteratureReference:508333] Human casein kinase Idelta phosphorylation of human circadian clock proteins period 1 and 2
modified	[InstanceEdit:9920763] May, Bruce, 2024-09-03 [InstanceEdit:9930079] May, Bruce, 2024-12-02 [InstanceEdit:9932107] May, Bruce, 2024-12-17 [InstanceEdit:9933409] May, Bruce, 2024-12-29 [InstanceEdit:9933511] May, Bruce, 2024-12-31 [InstanceEdit:9935064] May, Bruce, 2025-01-12 [InstanceEdit:9936865] May, Bruce, 2025-01-27 [InstanceEdit:9938453] May, Bruce, 2025-02-14 [InstanceEdit:9938697] May, Bruce, 2025-02-18 [InstanceEdit:9939392] May, Bruce, 2025-02-26
name	Formation of CRY:PER:Kinase complex
output	[Complex:9909381] CRY1:CRY2:PER1:p-S396-PER2:PER3:CSNK1E,CSNK1D [cytosol] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9922989] Phosphorylated BMAL1:CLOCK,NPAS2 and coactivators positively regulate expression of Cryptochrome-1 (CRY1) [Homo sapiens] [BlackBoxEvent:9920665] p-S90-BMAL1:p-T451,T461-CLOCK translocates from the cytosol to the nucleus [Homo sapiens] [Reaction:9922994] p-S90-BMAL1:p-T451,T461-CLOCK,p-NPAS2 and coactivators bind the CRY1 gene [Homo sapiens] [BlackBoxEvent:9925647] Phosphorylated BMAL1:CLOCK and coactivators positively regulate expression of Cryptochrome-2 (CRY2) [Homo sapiens] [Reaction:9925650] p-S90-BMAL1:p-T451,T461-CLOCK and coactivators bind the CRY2 gene [Homo sapiens] [BlackBoxEvent:9909561] Phosphorylated BMAL1:CLOCK,NPAS2 and coactivators positively regulate expression of Period-1 (PER1) [Homo sapiens] [Reaction:9922982] p-S90-BMAL1:p-T451,T461-CLOCK,p-NPAS2 and coactivators bind the PER1 gene [Homo sapiens] [Reaction:9920673] CDK5 phosphorylates PER2 on serine-396 [Homo sapiens] [BlackBoxEvent:9922990] Phosphorylated BMAL1:CLOCK,NPAS2 and coactivators positively regulate expression of Period-2 (PER2) [Homo sapiens] [BlackBoxEvent:9909374] Phosphorylated BMAL1:CLOCK and coactivators positively regulate expression of Period-3 (PER3) [Homo sapiens] [Reaction:9909400] p-S90-BMAL1:p-T451,T461-CLOCK and coactivators bind the PER3 gene [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-03-26
reviewed	[InstanceEdit:9938389] Sancar, Aziz, 2025-02-14 [InstanceEdit:9938694] Albrecht, Urs, 2025-02-18
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9909409] R-HSA-9909392.1
structureModified	[InstanceEdit:9920763] May, Bruce, 2024-09-03 [InstanceEdit:9933511] May, Bruce, 2024-12-31
summation	[Summation:9930073] Cryptochrome proteins (CRY1, CRY2), Period proteins (PER1, P...
(hasEvent)	[Pathway:9931530] Phosphorylation and nuclear translocation of the CRY:PER:kinase complex [Homo sapiens]
(precedingEvent)	[Reaction:9909369] CSNK1E,CSNK1D phosphorylate CRY and PER proteins [Homo sapiens]
(replacementInstances)	[_Deleted:9938764] Deletion of instance: 1856948
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No pathways have been reviewed or authored by Formation of CRY:PER:Kinase complex (9909392)